Evidence map›Paper›PMID 38068372›Full record

ArticleJournal of clinical medicine2023

Multi-Institutional Development and Validation of a Radiomic Model to Predict Prostate Cancer Recurrence Following Radical Prostatectomy.

Linda My Huynh, Benjamin Bonebrake, Joshua Tran, Jacob T Marasco, Thomas E Ahlering, Shuo Wang, Michael J Baine

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Linda My HuynhDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68105, USA.
Benjamin BonebrakeDepartment of Urology, University of Nebraska Medical Center, Omaha, NE 68105, USA.ORCID 0000-0001-8313-6971
Joshua TranDepartment of Urology, University of California, Irvine-Health Orange, Orange, CA 92868, USA.
Jacob T MarascoDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68105, USA.ORCID 0009-0001-5414-788X
Thomas E AhleringDepartment of Urology, University of California, Irvine-Health Orange, Orange, CA 92868, USA.ORCID 0000-0002-6492-4910
Shuo WangDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68105, USA.
Michael J BaineDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68105, USA.ORCID 0000-0002-1163-7539
University of California, Irvine · USUniversity of Nebraska Medical Center · USCreighton University · US

Funding

The Otis Glebe Medical Research Foundation 01100674 to S.W.
6 · The paper itself

Abstract

The use of multiparametric magnetic resonance imaging (mpMRI)-derived radiomics has the potential to offer noninvasive, imaging-based biomarkers for the identification of subvisual characteristics indicative of a poor oncologic outcome. The present study, therefore, seeks to develop, validate, and assess the performance of an MRI-derived radiomic model for the prediction of prostate cancer (PC) recurrence following radical prostatectomy (RP) with curative intent. mpMRI imaging was obtained from 251 patients who had undergone an RP for the treatment of localized prostate cancer across two institutions and three surgeons. All patients had a minimum of 2 years follow-up via prostate-specific antigen serum testing. Each prostate mpMRI was individually reviewed, and the prostate was delineated as a single slice (ROI) on axial T2 high-resolution image sets. A total of 924 radiomic features were extracted and tested for stability via intraclass correlation coefficient (ICC) following image normalization via histogram matching. Fourteen important and nonredundant features were found to be predictors of PC recurrence at a mean ± SD of 3.2 ± 2.2 years post-RP. Five-fold, ten-run cross-validation of the model containing these fourteen features yielded an area under the curve (AUC) of 0.89 ± 0.04 in the training set (

Indexed as

machine learningprostate cancerradiomicsrecurrence

Identifiers

PMID38068372
PMCPMC10707463
OpenAlexW4389049905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.