ArticleJournal of clinical medicine2023
Associations between Rheumatoid Arthritis and Various Comorbid Conditions in Germany-A Retrospective Cohort Study.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Causality between rheumatic diseases and iron-deficiency anemia: A 2-sample, 2-step mediation Mendelian randomization investigation.Medicine · 2025Article
- The Role of Artificial Intelligence in the Diagnosis and Management of Rheumatoid Arthritis.Medicina (Kaunas, Lithuania) · 2025Article
- From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases.Rheumatology and therapy · 2025Review
- Beyond joints: the importance of animal models in exploring rheumatoid arthritis comorbidities.Frontiers in medicine · 2025Review
- JAK Inhibitors in Rheumatoid Arthritis: Immunomodulatory Properties and Clinical Efficacy.International journal of molecular sciences · 2024Review
- Anemia and Its Connections to Inflammation in Older Adults: A Review.Journal of clinical medicine · 2024Review
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Authors and funding
6 authors.
Funding
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Abstract
aimsThe aim of the present study was to estimate the prevalence of physical and mental health comorbidities in patients with rheumatoid arthritis (RA) in Germany, in order to better understand the complex clinical picture and its consequences.
methodsThis retrospective cohort study was based on data from the IQVIA Disease Analyzer database and included individuals aged ≥ 16 years with an initial documented diagnosis of RA between 2015 and 2021 (index date). RA patients were matched 1:1 with non-RA individuals using nearest neighbor propensity score matching. The study investigated associations between RA and various disorders documented within 365 days after the index date. The cumulative incidence of defined disorders was calculated for individuals with and without RA. Multivariable logistic regression models were used to study these associations.
resultsData were available for a total of 49,713 patients with and 49,713 patients without RA (mean age: 60.4 (SD: 15.5) years; 66.7% female). A significant and clinically relevant positive association was observed between RA and seven disorders: soft tissue disorders (Odds Ratio (OR): 1.47; 95% Confidence Interval (CI): 1.42-1.52), renal failure (OR: 1.36; 95% CI: 1.26-1.47), anemia (OR: 1.32; 95% CI: 1.24-1.40), liver diseases (OR: 1.32, 95% CI: 1.23-1.41), osteopathies and chondropathies (OR: 1.28; 95% CI: 1.22-1.3), diseases of the esophagus, stomach and duodenum (OR: 1.18; 95% CI: 1.14-1.22), and nutritional deficiencies (OR: 1.17; 95% CI: 1.10-1.24).
conclusionsWe observed significant associations between RA and several comorbidities, which have clinical relevance for the care of RA patients not only in general practices but also in specialist settings.
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