Evidence map›Paper›PMID 38068265›Full record

ReviewJournal of clinical medicine2023

Biomarkers in Acute Myocarditis and Chronic Inflammatory Cardiomyopathy: An Updated Review of the Literature.

Giulia Crisci, Emanuele Bobbio, Piero Gentile, Daniel I Bromage, Entela Bollano, Emma Ferone, Muhammad Zubair Israr, Liam M Heaney, Christian L Polte, Antonio Cannatà and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Post-viral myocarditis.Heart failure reviews · 2026
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  17. Management Status of Myocarditis-Related Sudden Cardiac Death.Reviews in cardiovascular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Giulia CrisciDepartment of Translational Medical Sciences, Federico II University, 80131 Naples, Italy.
Emanuele BobbioDepartment of Cardiology, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.ORCID 0000-0002-8287-2448
Piero GentileDe Gasperis Cardio Center, Niguarda Hospital, 20162 Milan, Italy.
Daniel I BromageDepartment of Cardiology, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.
Entela BollanoDepartment of Cardiology, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.
Emma FeroneDepartment of Cardiology, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.
Muhammad Zubair IsrarDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Groby Road, Leicester LE3 9QP, UK.
Liam M HeaneySchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK.ORCID 0000-0002-8791-0167
Christian L PolteInstitute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, 41390 Gothenburg, Sweden.ORCID 0000-0001-7125-9747
Antonio CannatàDepartment of Cardiology, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.ORCID 0000-0001-7609-6297
Andrea SalzanoDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Groby Road, Leicester LE3 9QP, UK.ORCID 0000-0003-2352-2103
King's College London · GBSahlgrenska University Hospital · SEUniversity of Leicester · GBAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITFederico II University Hospital · ITLoughborough University · GB

Funding

Medical Research Council MR/X001881/1
6 · The paper itself

Abstract

Myocarditis is a disease caused by cardiac inflammation that can progress to dilated cardiomyopathy, heart failure, and eventually death. Several etiologies, including autoimmune, drug-induced, and infectious, lead to inflammation, which causes damage to the myocardium, followed by remodeling and fibrosis. Although there has been an increasing understanding of pathophysiology, early and accurate diagnosis, and effective treatment remain challenging due to the high heterogeneity. As a result, many patients have poor prognosis, with those surviving at risk of long-term sequelae. Current diagnostic methods, including imaging and endomyocardial biopsy, are, at times, expensive, invasive, and not always performed early enough to affect disease progression. Therefore, the identification of accurate, cost-effective, and prognostically informative biomarkers is critical for screening and treatment. The review then focuses on the biomarkers currently associated with these conditions, which have been extensively studied via blood tests and imaging techniques. The information within this review was retrieved through extensive literature research conducted on major publicly accessible databases and has been collated and revised by an international panel of experts. The biomarkers discussed in the article have shown great promise in clinical research studies and provide clinicians with essential tools for early diagnosis and improved outcomes.

Indexed as

biomarkerscardiac sarcoidosisheart failureimaginginflammatory heart diseasemyocarditis

Identifiers

PMID38068265
PMCPMC10706911
OpenAlexW4388857158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.