ReviewMolecules (Basel, Switzerland)2023
Design of Experiments for Optimizing Ultrasound-Assisted Extraction of Bioactive Compounds from Plant-Based Sources.
Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Fractional Factorial Design-Guided Optimization of Flavonoid Content and Antioxidant Capacity inPharmaceuticals (Basel, Switzerland) · 2026Article
- Bioactivity-Guided Optimization of 3-Deoxyanthocyanidin Extraction and Seasonal Mapping of Four Morphotypes ofInternational journal of molecular sciences · 2026Article
- Optimized Extraction and Bioactivity Profiling of Phenolics from Bostrychia scorpioides (Hudson) Mont: A Sustainable Approach for Pharmaceuticals Applications.Marine biotechnology (New York, N.Y.) · 2026Article
- Montmorillonite-fungal biomass hybrid as sustainable sorbent in rotating-disk sorptive extraction coupled to GC-MS for trace-level monitoring of estrogens in hospital wastewater.Analytical and bioanalytical chemistry · 2026Article
- Comparative Lipophilic Phytochemical Profiling and Bioactivity Assessment of Different Organs ofPlants (Basel, Switzerland) · 2026Article
- Ultrasound-assisted extraction of Ehretia macrophylla wall. Fruit phenolic acids: Process optimization, characterization, and lung protective activities.Ultrasonics sonochemistry · 2026Article
- Ultrasound-Assisted Extraction Coupled with Ion Chromatography for Benzoate Determination in Northern Thai Green Chili Dip: Box-Behnken Optimization, Greenness Assessment, and Application to Commercial Samples.Molecules (Basel, Switzerland) · 2026Article
- Optimizing Hydroalcoholic Extraction of African Medicinal Plants for Enhanced α-Amylase Inhibition and Functional Enrichment of Hypoglycemic Bread Doughs.Foods (Basel, Switzerland) · 2026Article
- Ultrasound and microwave assisted extraction of bioactives from food wastes: An overview on their comparative analysis towards commercialization.Ultrasonics sonochemistry · 2026Review
- Ultrasound-assisted extraction of bioactive compounds from pomegranate peel and seed: A comprehensive review of key parameters and optimization strategies.Ultrasonics sonochemistry · 2026Review
- Optimization of the Extraction of Bioactive Compounds and Metabolomic Profile ofPlants (Basel, Switzerland) · 2025Article
- Optimization of Anthocyanin Extraction from Purple Sweet Potato Peel (Foods (Basel, Switzerland) · 2025Article
- Ultrasound-assisted extraction, enrichment, and hypolipidemic potential of triterpenes from Grifola frondosa mycelia.BMC chemistry · 2025Article
- Optimization of Eudragit RS100 Nanocapsule Formulation for Encapsulating Perillyl Alcohol and Temozolomide Using Design of Experiments.ACS nanoscience Au · 2025Article
- Bioinputs fromMolecules (Basel, Switzerland) · 2025Article
- Antiviral alkaloids fromHeliyon · 2025Article
- Fermented soy products: A review of bioactives for health from fermentation to functionality.Comprehensive reviews in food science and food safety · 2025Review
- Impact of extraction techniques on phytochemical composition and bioactivity of natural product mixtures.Frontiers in pharmacology · 2025Review
- Ultrasound-Assisted Extraction of Bioactive Compounds from Broccoli By-Products.Foods (Basel, Switzerland) · 2024Article
- Screening factors to affect ultrasound-assisted extraction of (poly)phenols from date palm seeds.Frontiers in chemistry · 2024Article
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Authors and funding
11 authors.
Funding
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Abstract
Plant-based materials are an important source of bioactive compounds (BC) with interesting industrial applications. Therefore, adequate experimental strategies for maximizing their recovery yield are required. Among all procedures for extracting BC (maceration, Soxhlet, hydro-distillation, pulsed-electric field, enzyme, microwave, high hydrostatic pressure, and supercritical fluids), the ultrasound-assisted extraction (UAE) highlighted as an advanced, cost-efficient, eco-friendly, and sustainable alternative for recovering BC (polyphenols, flavonoids, anthocyanins, and carotenoids) from plant sources with higher yields. However, the UAE efficiency is influenced by several factors, including operational variables and extraction process (frequency, amplitude, ultrasonic power, pulse cycle, type of solvent, extraction time, solvent-to-solid ratio, pH, particle size, and temperature) that exert an impact on the molecular structures of targeted molecules, leading to variations in their biological properties. In this context, a diverse design of experiments (DOEs), including full or fractional factorial, Plackett-Burman, Box-Behnken, Central composite, Taguchi, Mixture, D-optimal, and Doehlert have been investigated alone and in combination to optimize the UAE of BC from plant-based materials, using the response surface methodology and mathematical models in a simple or multi-factorial/multi-response approach. The present review summarizes the advantages and limitations of the most common DOEs investigated to optimize the UAE of bioactive compounds from plant-based materials.
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