Evidence map›Paper›PMID 38067439›Full record

ArticleMolecules (Basel, Switzerland)2023

Potent MOR Agonists from 2'-Hydroxy-5,9-dimethyl-

Madhurima Das, George W Ward, Agnieszka Sulima, Dan Luo, Thomas Edward Prisinzano, Gregory H Imler, Andrew T Kerr, Arthur E Jacobson, Kenner C Rice

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Madhurima DasDrug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0002-1840-6493
George W WardDrug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, MD 20892, USA.
Agnieszka SulimaDrug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, MD 20892, USA.
Dan LuoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone Street, Lexington, KY 40536, USA.
Thomas Edward PrisinzanoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone Street, Lexington, KY 40536, USA.ORCID 0000-0002-0649-8052
Gregory H ImlerCenter for Biomolecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375, USA.
Andrew T KerrCenter for Biomolecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375, USA.
Arthur E JacobsonDrug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0002-0011-8354
Kenner C RiceDrug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0002-1147-9147
National Institute on Drug Abuse · USUnited States Naval Research Laboratory · USUniversity of Kentucky · US

Funding

Development of Agents for Synthetic Opioid OverdoseU01DA051377 · NIDA · UNIVERSITY OF KENTUCKY · PI PRISINZANO, THOMAS EDWARD · 2021 to 2023
$1.4M
BRIDGING THE DISCONNECTN01DA001101 · NIDA · MANAGEMENT ASSISTANCE CORPORATION · PI FISCHER, GLENN · 2000 to 2000
$322k
NIDA NIH HHS DA051377NIDA NIH HHS Interagency Agreement #Y1-DA1101NIDA NIH HHS U01 DA051377
6 · The paper itself

Abstract

(-)-5,9-Dimethyl-6,7-benzomorphan (normetazocine) derivatives with a

Indexed as

BenzomorphansMorphineEthylaminesIndolesStructure-Activity RelationshipBenzomorphansEthylaminesIndolesMorphineC8-alkenyl substituted 6,7-benzomorphansC8-alkyl substituted 6,7-benzomorphansinhibition of forskolin-induced cAMP accumulation assay (cAMP assay)N-phenethyl analogs of 6,7-benzomorphansN-phenethylnormetazocine derivativesopioid

Identifiers

PMID38067439
PMCPMC10708259
OpenAlexW4388901995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.