Evidence map›Paper›PMID 38067359›Full record

ArticleCancers2023

High-Pressure Delivery of Oncolytic Viruses via Needle-Free Injection Preserves Therapeutic Activity.

Aida Said, Huy-Dung Hoang, Nathalie Earl, Xiao Xiang, Nadeem Siddiqui, Marceline Côté, Tommy Alain

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Aida SaidDepartment of Biochemistry Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Huy-Dung HoangDepartment of Biochemistry Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Nathalie EarlChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada.
Xiao XiangDepartment of Biochemistry Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.ORCID 0000-0002-3969-1668
Nadeem SiddiquiDepartment of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
Marceline CôtéDepartment of Biochemistry Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.ORCID 0000-0002-4664-4325
Tommy AlainDepartment of Biochemistry Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.ORCID 0000-0002-0396-9138
University of Ottawa · CAChildren's Hospital of Eastern Ontario · CAMcGill University · CA

Funding

CIHR -NA-
6 · The paper itself

Abstract

Intratumoural delivery of oncolytic viruses (OVs) to solid tumours is currently performed via multiple percutaneous methods of needle injections (NI). In this study, we investigated the potential use of a novel delivery approach, needle-free injection (NFI), to administer OVs to subcutaneous tumours. The stability and genetic integrity of several RNA and DNA viruses exposed to high-pressure jet injectors were first evaluated in vitro. We demonstrate that replication competence and infectivity of the viruses remained unchanged after NFI, as compared to traditional NI. Using the oncolytic Vesicular Stomatitis Virus expressing luciferase (VSVΔ51-Luc) in the syngeneic CT26 subcutaneous tumour model, we show that NFI administration not only successfully delivers infectious particles but also increases the dissemination of the virus within the tumour tissues when compared to NI. Furthermore, mice treated with VSVΔ51-Luc by NFI delivery showed similar reduction in tumour growth and survival compared to those with needle-administered virus. These results indicate that NFI represents a novel approach to administer and potentially increase the spread of OVs within accessible solid tumours, highlighting its usefulness in virotherapy.

Indexed as

immunotherapyneedle-free injectiononcolytic virustumour

Identifiers

PMID38067359
PMCPMC10705192
OpenAlexW4389203499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.