Evidence map›Paper›PMID 38067301›Full record

ArticleCancers2023

Identifying Predictive Biomarkers for Head and Neck Squamous Cell Carcinoma Response.

Anne-Sophie Becker, Cornelius Kluge, Carsten Schofeld, Annette Helene Zimpfer, Björn Schneider, Daniel Strüder, Caterina Redwanz, Julika Ribbat-Idel, Christian Idel, Claudia Maletzki

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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  6. Transcriptome-based model for predicting radiotherapy response in HNSCC patients.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Anne-Sophie BeckerInstitute of Pathology, Rostock University Medical Center, 18057 Rostock, Germany.
Cornelius KlugeInstitute of Pathology, Rostock University Medical Center, 18057 Rostock, Germany.
Carsten SchofeldInstitute of Pathology, Rostock University Medical Center, 18057 Rostock, Germany.
Annette Helene ZimpferInstitute of Pathology, Rostock University Medical Center, 18057 Rostock, Germany.
Björn SchneiderInstitute of Pathology, Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0000-0002-0282-7330
Daniel StrüderDepartment of Otorhinolaryngology, Head and Neck Surgery "Otto Koerner", Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0000-0002-9383-1756
Caterina RedwanzDepartment of Internal Medicine B, Cardiology, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0009-0005-7815-0994
Julika Ribbat-IdelInstitute of Pathology, University of Luebeck, University Hospital Schleswig-Holstein, Campus Luebeck, 23538 Luebeck, Germany.
Christian IdelDepartment of Oto-Rhino-Laryngology & Head and Neck Surgery, University of Lubeck, University Hospital Schleswig-Holstein, Campus Luebeck, 23538 Luebeck, Germany.
Claudia MaletzkiDepartment of Internal Medicine, Medical Clinic III-Hematology, Oncology, Palliative Medicine, Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0000-0002-8389-8439
University of Rostock · DEUniversity Hospital Schleswig-Holstein · DEUniversitätsmedizin Greifswald · DE

Funding

Universitätsmedizin Rostock 889038
6 · The paper itself

Abstract

The 5-year survival rate for head and neck squamous cell carcinoma (HNSCC) is approximately 65%. In addition to radio-chemotherapy, immunotherapy is an approach in the treatment of advanced HNSCC. A better understanding of the immune context would allow personalized treatment by identifying patients who are best suited for different treatment options. In our discovery cohort, we evaluated the expression profiles of CMTM6, PD-L1, CTLA-4, and FOXP3 in 177 HNSCCs from Caucasian patients of all tumor stages and different treatment regimens, correlating marker expression in tumor and immune cells with outcomes. Patients with CMTM6

Indexed as

cisplatinCMTM6HNSCCimmune-checkpoint inhibitorPD-L1radiotherapytumor microenvironment

Identifiers

PMID38067301
PMCPMC10705351
OpenAlexW4389051158

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.