ArticleCancers2023
Quality of Life and Independent Factors Associated with Poor Digestive Function after Ivor Lewis Esophagectomy.
Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.
- Prophylactic pyloric drainage for prevention of delayed gastric conduit emptying following Ivor Lewis esophagectomy: a systematic review with exploratory synthesis.Surgical endoscopy · 2026Pooled it
- Systematic Review and Meta-Analysis of Patient Experiences of Oesophageal Cancer Survivorship After Oesophagectomy.Psycho-oncology · 2026Pooled it
- Applicability and results of the consensus definition of delayed gastric conduit emptying after esophagectomy.Langenbeck's archives of surgery · 2026Article
- Revisional surgery for delayed gastric conduit emptying after esophagectomy: the RESTORANT project.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2026Article
- Prediction of dumping after oesophageal cancer surgery.Acta oncologica (Stockholm, Sweden) · 2026Article
- Endoscopic Submucosal Dissection and Chemoradiotherapy versus Esophagectomy for T1a-m3 or T1b Esophageal Squamous Cell Carcinoma: A Meta-analysis.Endoscopy international open · 2026Review
- Delayed gastric conduit emptying after esophagectomy: attempt at a clinically relevant classification.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025Article
- Post-Esophagectomy Dumping Syndrome: Assessing Quality of Life of Long-Term Survivors.Journal of clinical medicine · 2025Article
- Premature mortality for patients after completely resected early adenocarcinoma of the esophagus or stomach.Cancer medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transthoracic esophagectomy results in a radical change in foregut anatomy with multiple consequences for digestive physiology. The aim of this study was to identify factors associated with poor functional outcomes by assessing multiple dimensions of digestive performance and health-related quality of life (HRQL). Patients with cancer-free survival after Ivor Lewis esophagectomy were included. Four functional syndromes (dysphagia, gastroesophageal reflux disease (GERD), delayed gastric conduit emptying (DGCE), and dumping syndrome (DS)) and HRQL were assessed using specifically designed questionnaires. Patient outcomes were compared with healthy controls. Independent factors associated with poor digestive performance were identified through multivariable analysis. Sixty-five postoperative patients and 50 healthy volunteers participated in this study. Compared with controls, patients had worse outcomes for dysphagia, GERD, DS, and HRQL, but not for DGCE. A multivariate analysis showed a significant correlation of reduced digestive performance with ASA score, squamous cell carcinoma, open or hybrid surgical approach, and (neo)adjuvant therapy. In contrast, no individual patient factor was found to be associated with dumping syndrome. Digestive function and HRQL are substantially impaired after Ivor Lewis esophagectomy for cancer. Comorbid patients undergoing multimodal treatment and open access surgery for squamous cell carcinoma have the highest risk of poor functional outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.