Evidence map›Paper›PMID 38067234›Full record

ArticleCancers2023

Analysis of the Tumor Immune Microenvironment (TIME) in Clear Cell Renal Cell Carcinoma (ccRCC) Reveals an M0 Macrophage-Enriched Subtype: An Exploration of Prognostic and Biological Characteristics of This Immune Phenotype.

Mark Farha, Srinivas Nallandhighal, Randy Vince, Brittney Cotta, Judith Stangl-Kremser, Daniel Triner, Todd M Morgan, Ganesh S Palapattu, Marcin Cieslik, Ulka Vaishampayan and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Mark FarhaDepartment of Medical Education, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Srinivas NallandhighalDepartment of Urology, Michigan Medicine, Ann Arbor, MI 48109, USA.
Randy VinceDepartment of Urology, Michigan Medicine, Ann Arbor, MI 48109, USA.
Brittney CottaDepartment of Urology, Michigan Medicine, Ann Arbor, MI 48109, USA.
Judith Stangl-KremserDepartment of Urology, Michigan Medicine, Ann Arbor, MI 48109, USA.
Daniel TrinerDepartment of Urology, Michigan Medicine, Ann Arbor, MI 48109, USA.
Todd M MorganDepartment of Urology, Michigan Medicine, Ann Arbor, MI 48109, USA.
Ganesh S PalapattuDepartment of Medical Education, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Marcin CieslikRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Ulka VaishampayanDepartment of Medical Education, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Aaron M UdagerRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8254-5404
Simpa S SalamiDepartment of Medical Education, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7461-7079
University of Michigan · USMichigan Medicine · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Tissue/InformaticsP50CA186786 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Timothy Dess · 2014 to 2026
$27.6M
Real time fine needle assessment of architectural heterogeneity in prostate cancerR37CA222829 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, GUAN · 2019 to 2025
$3.2M
Biomarker-Based Tools for Treatment Response Decision Support of Bladder CancerU01CA232931 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALVA, AJJAI SHIVARAM, HADJIYSKI, LUBOMIR M · 2019 to 2024
$3.1M
NCI NIH HHS P30 CA046592NCI NIH HHS P50 CA186786NCI NIH HHS R37 CA222829NCI NIH HHS U01 CA232931
6 · The paper itself

Abstract

There is a need to optimize the treatment of clear cell renal cell carcinoma (ccRCC) patients at high recurrence risk after nephrectomy. We sought to elucidate the tumor immune microenvironment (TIME) of localized ccRCC and understand the prognostic and predictive characteristics of certain features. The discovery cohort was clinically localized patients in the TCGA-Kidney Renal Clear Cell Carcinoma (KIRC) project (

Indexed as

biomarkersclear cell renal cell carcinoma (ccRCC)genomicsimmune checkpoint blockademacrophagestumor immune microenvironment (TIME)

Identifiers

PMID38067234
PMCPMC10705373
OpenAlexW4388908862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.