ReviewCells2023
The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders.
Review in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 294 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
294 citing papers in PubMed, 2 syntheses or guidelines pooled it, 391 citations in OpenAlex.
- Biological Markers of Burnout Severity: A Systematic Review.Stress and health : journal of the International Society for the Investigation of Stress · 2026Pooled it
- Impact of probiotic supplementation on cortisol levels; GRADE-based dose-response meta-analysis.BMC nutrition · 2026Pooled it
- Reducing concerns about falling in older adults: evaluation of a multi-component intervention and the role of stress and inflammation markers - long-term effects of the FEARFALL randomized controlled trial.Aging clinical and experimental research · 2026Trial
- Effect of cognitive behavioral therapy on anxiety and pregnancy outcomes in mothers with IUGR: an assessor-blinded randomized controlled trial.BMC pregnancy and childbirth · 2026Trial
- From screens to serenity: evaluating the effect of digital detox on mental and physiological health.BMC medical education · 2025Trial
- Decoding the HMO‒microbiome axis: bridging maternal milk to infant health outcomes.Gut microbes · 2026Review
- Psychological and biological long-term consequences of trauma in the Yazidi population displaced from Shingal after the genocide.European journal of psychotraumatology · 2026Article
- Oxytocin as regulator of stress and inflammation in aging.Neuroscience and biobehavioral reviews · 2026Review
- Silibinin Alleviates Cognitive Dysfunction, Biochemical Alterations, and Hippocampal Structural Changes Induced by 5 days of Sleep Deprivation with or Without a Subsequent 24-H Recovery in Rats.Molecular neurobiology · 2026Article
- Beyond genetics: how environmental stressors drive pediatric hypertension risk.Pediatric nephrology (Berlin, Germany) · 2026Review
- Stress, needs, and behaviour: understanding chronic stress in pet domestic dogs (Canis lupus familiaris) from the prism of needs.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Positive association between sex hormones and inflammatory cytokines in trauma-exposed premenopausal women.Brain, behavior, & immunity - health · 2026Article
- Establishment of a reference range for hair cortisol using a HPLC-MS/MS method in a Northern Italian population.Journal of endocrinological investigation · 2026Article
- Comprehensive Health Predictors of Injury, Illness, and Separation From Service After Enrollment in Special Forces Assessment and Selection: A Two-Year Longitudinal Study.Stress and health : journal of the International Society for the Investigation of Stress · 2026Article
- Bovine appeasing pheromone mitigates long-distance transport stress to improve health and growth performance in beef cattle.Tropical animal health and production · 2026Article
- Stress Urinary Incontinence as a Chronic Stress Model: Clinical Evidence and Emerging Epigenetic Implications for Mental Disorders.Biomedicines · 2026Article
- From Cellular Stress to Systemic Adaptation: The Circadian Clock and Stress Response at Cellular and Systemic Levels.International journal of molecular sciences · 2026Review
- Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications.Neuroprotection (Chichester, England) · 2026Review
- The Mediating Effect of Physiological Health Fear Between Depressive Mood and Sleep Quality in Elderly Parkinson's Disease Patients.Brain and behavior · 2026Article
- A comprehensive longitudinal study quantifying the systemic effects associated with ovariectomy and high-dose corticosteroids in a sheep model of osteoporosis.Annals of translational medicine · 2026Article
234 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortisol, a critical glucocorticoid hormone produced by the adrenal glands, plays a pivotal role in various physiological processes. Its release is finely orchestrated by the suprachiasmatic nucleus, governing the circadian rhythm and activating the intricate hypothalamic-pituitary-adrenal (HPA) axis, a vital neuroendocrine system responsible for stress response and maintaining homeostasis. Disruptions in cortisol regulation due to chronic stress, disease, and aging have profound implications for multiple bodily systems. Animal models have been instrumental in elucidating these complex cortisol dynamics during stress, shedding light on the interplay between physiological, neuroendocrine, and immune factors in the stress response. These models have also revealed the impact of various stressors, including social hierarchies, highlighting the role of social factors in cortisol regulation. Moreover, chronic stress is closely linked to the progression of neurodegenerative diseases, like Alzheimer's and Parkinson's, driven by excessive cortisol production and HPA axis dysregulation, along with neuroinflammation in the central nervous system. The relationship between cortisol dysregulation and major depressive disorder is complex, characterized by HPA axis hyperactivity and chronic inflammation. Lastly, chronic pain is associated with abnormal cortisol patterns that heighten pain sensitivity and susceptibility. Understanding these multifaceted mechanisms and their effects is essential, as they offer insights into potential interventions to mitigate the detrimental consequences of chronic stress and cortisol dysregulation in these conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.