Evidence map›Paper›PMID 38067139›Full record

ArticleCells2023

Repeated Intravenous Administration of Human Neural Stem Cells Producing Choline Acetyltransferase Exerts Anti-Aging Effects in Male F344 Rats.

Jangbeen Kyung, Dajeong Kim, Kyungha Shin, Dongsun Park, Soon-Cheol Hong, Tae Myoung Kim, Ehn-Kyoung Choi, Yun-Bae Kim

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jangbeen KyungCollege of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.
Dajeong KimCollege of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.
Kyungha ShinCollege of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.
Dongsun ParkDepartment of Biology Education, Korea National University of Education, Cheongju 28173, Republic of Korea.
Soon-Cheol HongDepartment of Obstetrics and Gynecology, Korea University College of Medicine, Seoul 02841, Republic of Korea.ORCID 0000-0002-9330-7620
Tae Myoung KimCentral Research Institute, Designed Cells Co., Ltd., Cheongju 28576, Republic of Korea.
Ehn-Kyoung ChoiCentral Research Institute, Designed Cells Co., Ltd., Cheongju 28576, Republic of Korea.
Yun-Bae KimCollege of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.ORCID 0000-0003-1340-041X
Chungbuk National University · KRKorea National University of Education · KRKorea University · KR

Funding

Korea Health Industry Development Institute HI22C1650National Research Foundation of Korea 2021RIS-001
6 · The paper itself

Abstract

Major features of aging might be progressive decreases in cognitive function and physical activity, in addition to withered appearance. Previously, we reported that the intracerebroventricular injection of human neural stem cells (NSCs named F3) encoded the choline acetyltransferase gene (F3.ChAT). The cells secreted acetylcholine and growth factors (GFs) and neurotrophic factors (NFs), thereby improving learning and memory function as well as the physical activity of aged animals. In this study, F344 rats (10 months old) were intravenously transplanted with F3 or F3.ChAT NSCs (1 × 10

Indexed as

AcetylcholineNeural Stem CellsAdministration, IntravenousAgedAgingAnimalsCholine O-AcetyltransferaseCholinergic AgentsHumansInfantMaleMaze LearningRatsRats, Inbred F344AcetylcholineCholine O-AcetyltransferaseCholinergic Agentsacetylcholineagingcholine acetyltransferasecognitive functiongrowth factorhuman neural stem cellneurotrophic factorphysical activity

Identifiers

PMID38067139
PMCPMC10706332
OpenAlexW4389056611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.