Evidence map›Paper›PMID 38067107›Full record

ArticleCells2023

Liquid Biopsy in Alzheimer's Disease Patients Reveals Epigenetic Changes in the

Mónica Macías, Blanca Acha, Jon Corroza, Amaya Urdánoz-Casado, Miren Roldan, Maitane Robles, Javier Sánchez-Ruiz de Gordoa, María Elena Erro, Ivonne Jericó, Idoia Blanco-Luquin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Mónica MacíasNavarrabiomed, Hospital Universitario de Navarra, Universidad Pública de Navarra, IdiSNA, 31008 Pamplona, Spain.ORCID 0000-0002-1550-0716
Blanca AchaNavarrabiomed, Hospital Universitario de Navarra, Universidad Pública de Navarra, IdiSNA, 31008 Pamplona, Spain.
Jon CorrozaNeurology Department, Hospital Universitario de Navarra, IdiSNA, 31008 Pamplona, Spain.
Amaya Urdánoz-CasadoNavarrabiomed, Hospital Universitario de Navarra, Universidad Pública de Navarra, IdiSNA, 31008 Pamplona, Spain.ORCID 0000-0002-6312-8330
Miren RoldanNavarrabiomed, Hospital Universitario de Navarra, Universidad Pública de Navarra, IdiSNA, 31008 Pamplona, Spain.ORCID 0000-0002-7102-569X
Maitane RoblesNavarrabiomed, Hospital Universitario de Navarra, Universidad Pública de Navarra, IdiSNA, 31008 Pamplona, Spain.
Javier Sánchez-Ruiz de GordoaNavarrabiomed, Hospital Universitario de Navarra, Universidad Pública de Navarra, IdiSNA, 31008 Pamplona, Spain.
María Elena ErroNavarrabiomed, Hospital Universitario de Navarra, Universidad Pública de Navarra, IdiSNA, 31008 Pamplona, Spain.
Ivonne JericóNeurology Department, Hospital Universitario de Navarra, IdiSNA, 31008 Pamplona, Spain.ORCID 0000-0003-4262-6370
Idoia Blanco-LuquinNavarrabiomed, Hospital Universitario de Navarra, Universidad Pública de Navarra, IdiSNA, 31008 Pamplona, Spain.ORCID 0000-0003-2917-586X
Maite MendiorozNavarrabiomed, Hospital Universitario de Navarra, Universidad Pública de Navarra, IdiSNA, 31008 Pamplona, Spain.ORCID 0000-0002-4179-5781
Universidad Publica de Navarra · ES

Funding

Fundación Luzón HR20-01109_BIOP-ALSGobierno de Navarra Doctorando industrial 2018-2020Gobierno de Navarra GºNa 36/18Gobierno de Navarra Predoctoral 2019Instituto de Salud Carlos III Contrato de intensificación INT19/00029Instituto de Salud Carlos III PFIS fellowship FI18/00150Instituto de Salud Carlos III PI20/01701Instituto de Salud Carlos III Rio Hortega CM20/00240La Caixa Foundation LCF/PR/PR15/51100006LaCaixa Foundation 100010434
6 · The paper itself

Abstract

In recent years, new DNA methylation variants have been reported in genes biologically relevant to Alzheimer's disease (AD) in human brain tissue. However, this AD-specific epigenetic information remains brain-locked and unreachable during patients' lifetimes. In a previous methylome performed in the hippocampus of 26 AD patients and 12 controls, we found higher methylation levels in AD patients in the promoter region of

Indexed as

Alzheimer DiseaseCell-Free Nucleic AcidsEpigenesis, GeneticLiquid BiopsyDNA MethylationHumansCell-Free Nucleic Acids450K arrayAlzheimer’s diseasecell-free DNADNA methylationliquid biopsyPRLHRProlactin releasing-peptide (PrRP)

Identifiers

PMID38067107
PMCPMC10705731
OpenAlexW4388906206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.