Evidence map›Paper›PMID 38067102›Full record

ArticleCells2023

RhoA Is a Crucial Regulator of Myoblast Fusion.

Chiara Noviello, Kassandra Kobon, Voahangy Randrianarison-Huetz, Pascal Maire, France Pietri-Rouxel, Sestina Falcone, Athanassia Sotiropoulos

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Epithelial cell fusion is required for tissue repair following UV-A irradiation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chiara NovielloInstitut Cochin, Université de Paris, INSERM U1016, CNRS, F-75014 Paris, France.
Kassandra KobonInstitut Cochin, Université de Paris, INSERM U1016, CNRS, F-75014 Paris, France.
Voahangy Randrianarison-HuetzInstitut Cochin, Université de Paris, INSERM U1016, CNRS, F-75014 Paris, France.
Pascal MaireInstitut Cochin, Université de Paris, INSERM U1016, CNRS, F-75014 Paris, France.ORCID 0000-0001-7795-0029
France Pietri-RouxelCentre de Recherche en Myologie, Sorbonne Université, INSERM UMRS 974, Institut de Myologie, F-75013 Paris, France.ORCID 0000-0002-6258-7594
Sestina FalconeCentre de Recherche en Myologie, Sorbonne Université, INSERM UMRS 974, Institut de Myologie, F-75013 Paris, France.ORCID 0000-0002-3574-0602
Athanassia SotiropoulosInstitut Cochin, Université de Paris, INSERM U1016, CNRS, F-75014 Paris, France.ORCID 0000-0002-7265-1473
Centre National de la Recherche Scientifique · FRInserm · FR

Funding

French Muscular Dystrophy Association 22365 and 22776IdEx Emergence Université de Paris IP 2019-030
6 · The paper itself

Abstract

Satellite cells (SCs) are adult muscle stem cells that are mobilized when muscle homeostasis is perturbed. Here we show that RhoA in SCs is indispensable to have correct muscle regeneration and hypertrophy. In particular, the absence of RhoA in SCs prevents a correct SC fusion both to other RhoA-deleted SCs (regeneration context) and to growing control myofibers (hypertrophy context). We demonstrated that RhoA is dispensable for SCs proliferation and differentiation; however, RhoA-deleted SCs have an inefficient movement even if their cytoskeleton assembly is not altered. Proliferative myoblast and differentiated myotubes without RhoA display a decreased expression of

Indexed as

Cell FusionMuscle Fibers, SkeletalrhoA GTP-Binding ProteinSatellite Cells, Skeletal MuscleCell CommunicationHumansHypertrophyrhoA GTP-Binding ProteinRHOA protein, humanadult muscle stem cellsmuscle cell fusionmuscle damagemuscle hypertrophymuscle regenerationsmall GTPase proteins

Identifiers

PMID38067102
PMCPMC10705320
OpenAlexW4388860849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.