Evidence map›Paper›PMID 38067097›Full record

ArticleCells2023

Patterns of Gene Expression, Splicing, and Allele-Specific Expression Vary among Macular Tissues and Clinical Stages of Age-Related Macular Degeneration.

Treefa Shwani, Charles Zhang, Leah A Owen, Akbar Shakoor, Albert T Vitale, John H Lillvis, Julie L Barr, Parker Cromwell, Robert Finley, Nadine Husami and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Characterization of hydrolase activity in ocular tissues of humans and preclinical species.Drug metabolism and disposition: the biological fate of chemicals · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 8 institutions in 1 country.

Treefa ShwaniDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
Charles ZhangDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
Leah A OwenDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.ORCID 0000-0003-3802-3868
Akbar ShakoorDepartment of Ophthalmology and Visual Sciences, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.
Albert T VitaleDepartment of Ophthalmology and Visual Sciences, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.
John H LillvisDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.ORCID 0000-0001-8274-8511
Julie L BarrDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
Parker CromwellDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
Robert FinleyDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
Nadine HusamiDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
Elizabeth AuDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
Rylee A ZavalaDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
Elijah C GravesDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
Sarah X ZhangDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
Michael H FarkasDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
David A AmmarLion's Eye Institute for Transplant & Research, Tampa, FL 33605, USA.ORCID 0000-0002-7848-7192
Karen M AllisonDepartment of Ophthalmology, Flaum Eye Institute, University of Rochester, Rochester, NY 14642, USA.
Amany TawfikDepartment of Foundational Medical Studies and Eye Research Center, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USA.ORCID 0000-0002-0245-8256
Richard M ShervaDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Mingyao LiDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dwight StambolianDepartment of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ivana K KimRetina Service, Massachusetts Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Lindsay A FarrerDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0001-5533-4225
Margaret M DeAngelisDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.ORCID 0000-0003-3731-142X
New York University · USUniversity of Utah · USBoston University · USUniversity of Pennsylvania · USVA Western New York Healthcare System · USMassachusetts Eye and Ear Infirmary · USOakland University · USUniversity of Rochester · US

Funding

Use of Rapamycin for the Treatment of Hypertrophic Cardiomyopathy in Patients with Noonan Syndrome with Multiple Lentigines (NSML)ZIATR000012 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI OTTINGER, ELIZABETH · 2015 to 2019
$8.2M
Deconstructing and Modeling the Single Cell Architecture of the Age-Related Macular Degeneration Retina and RPE/ChoroidR01EY031209 · NEI · UNIVERSITY OF PENNSYLVANIA · PI DEANGELIS, MARGARET M, LI, MINGYAO · 2020 to 2024
$2.7M
Homocysteine's role in Age-Related Macular DegenerationR01EY029751 · NEI · OAKLAND UNIVERSITY · PI TAWFIK, AMANY M · 2019 to 2023
$1.8M
Systems-Biology Analysis of Mechanisms Informing Preeclampsia-Mediated ROP ProtectionK08EY031800 · NEI · UNIVERSITY OF UTAH · PI OWEN, LEAH A · 2020 to 2022
$497k
NCATS NIH HHS UL1TR0012-05NEI NIH HHS 1K08EY031800-01NEI NIH HHS K08 EY031800NEI NIH HHS R01 EY029751NEI NIH HHS R01 EY031209
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is a leading cause of blindness, and elucidating its underlying disease mechanisms is vital to the development of appropriate therapeutics. We identified differentially expressed genes (DEGs) and differentially spliced genes (DSGs) across the clinical stages of AMD in disease-affected tissue, the macular retina pigment epithelium (RPE)/choroid and the macular neural retina within the same eye. We utilized 27 deeply phenotyped donor eyes (recovered within a 6 h postmortem interval time) from Caucasian donors (60-94 years) using a standardized published protocol. Significant findings were then validated in an independent set of well-characterized donor eyes (

Indexed as

Serine-Type D-Ala-D-Ala CarboxypeptidaseWet Macular DegenerationAllelesAngiogenesis InhibitorsCarrier ProteinsCytoskeletal ProteinsGene ExpressionGTP-Binding ProteinsHumansNerve Tissue ProteinsPhosphate-Binding ProteinsVascular Endothelial Growth Factor AVisual AcuityAGTPBP1 protein, humanAngiogenesis InhibitorsBBS5 protein, humanCarrier ProteinsCytoskeletal ProteinsGTP-Binding ProteinsNerve Tissue ProteinsPhosphate-Binding ProteinsSerine-Type D-Ala-D-Ala CarboxypeptidaseVascular Endothelial Growth Factor AZNF292 protein, humanage-related macular degeneration (AMD)allele-specific expression (ASE)and AMD therapiesintermediate AMD (iAMD)macular retinamacular retinal pigment epithelium (RPE)/choroidmicroRNAs (miRNAs)neovascular AMD (NEO)splicingtissue-specific gene expression

Identifiers

PMID38067097
PMCPMC10705168
OpenAlexW4388849197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.