ArticleHematology. American Society of Hematology. Education Program2023
Sex, lies, and iron deficiency: a call to change ferritin reference ranges.
Article in Hematology. American Society of Hematology. Education Program, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Cost-effectiveness of iron deficiency screening in pregnancy across ferritin-based thresholds.Blood advances · 2026Article
- Age- and sex-specific patterns of microcytic anemia in adolescence: implications for screening.European journal of pediatrics · 2026Article
- Call to action: identifying an underlying bleeding disorder in adolescents with heavy menstrual bleeding.Research and practice in thrombosis and haemostasis · 2026Review
- Article
- Reference Intervals for Serum Ferritin in Older Adults-Results from the Prospective SENIORLAB Study.Journal of clinical medicine · 2026Article
- Nonanemic Iron Deficiency: Exercise Performance Recovery After Iron Repletion in Collegiate Athlete.JACC. Case reports · 2026Article
- Prevalence of Ferritin Testing, Iron Deficiency, and Iron Supplementation Among Women with Fatigue in Ambulatory Care.Journal of general internal medicine · 2026Article
- Anemia, iron deficiency, and blood biomarkers for Alzheimer disease: clinical interpretation and dementia risk stratification.Frontiers in nutrition · 2026Review
- Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression.Blood advances · 2025Article
- 'Raise the Bar', a Canadian intervention to combat disparities in the recognition and management of iron deficiency: Development of the intervention, feasibility and implementation.British journal of haematology · 2025Article
- Iron deficiency and iron deficiency anemia in inherited bleeding disorders: common, underrecognized, and undertreated.Research and practice in thrombosis and haemostasis · 2025Article
- Is it time to offer routine screening for iron deficiency in healthy adolescent females?British journal of haematology · 2025Review
- Review
- Diagnosis and management of iron deficiency in females.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Review
- Cost-Effectiveness of Ferritin Screening Thresholds for Iron Deficiency in Reproductive-Age Women.American journal of hematology · 2025Article
- Topics of Interest in Women With Myeloproliferative Neoplasms.American journal of hematology · 2025Review
- [Practice-oriented rational assessment of anemia].Innere Medizin (Heidelberg, Germany) · 2025Review
- Iron Deficiency in Collegiate Athletes Obtaining Preparticipation Hemoglobinopathy Screening in the Upper Midwest.Pediatric blood & cancer · 2025Article
- Defining Global Thresholds for Serum Ferritin: A Challenging Mission in Establishing the Iron Deficiency Diagnosis in This Era of Striving for Health Equity.Diagnostics (Basel, Switzerland) · 2025Review
- Iron Deficiency-More Than Just Anemia: A Literature Review.Journal of community hospital internal medicine perspectives · 2025Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron deficiency is a very common and treatable disorder. Of all the tests available to diagnose iron deficiency, the serum ferritin is the most able to discriminate iron deficiency from other disorders. However, the reference range for ferritin in many laboratories will lead to underdiagnosis of iron deficiency in women. Studies have shown that 30%-50% of healthy women will have no marrow iron stores, so basing ferritin cutoffs on the lowest 2.5% of sampled ferritins is not appropriate. In addition, several lines of evidence suggest the body physiologic ferritin "cutoff" is 50 ng/mL. Work is needed to establish more realistic ferritin ranges to avoid underdiagnosing a readily treatable disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.