Evidence map›Paper›PMID 38066673›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2024

From Evidence to Effectiveness: Implications of the Randomized Trial to Prevent Vascular Events in HIV Study for People With HIV in Low- and Middle-Income Settings.

Jennifer Manne-Goehler, Mohammed K Ali, David Flood, Vincent C Marconi, Willem D F Venter, Mark J Siedner

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Jennifer Manne-GoehlerDivision of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-9295-0035
Mohammed K AliEmory Global Diabetes Research Center of Woodruff Health Sciences Center and Emory University, Atlanta, Georgia, USA.
David FloodDepartment of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Vincent C MarconiHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Willem D F VenterWits Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Mark J SiednerMedical Practice Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Emory University · USBrigham and Women's Hospital · USHarvard University · USUniversity of Michigan · USUniversity of the Witwatersrand · ZA

Funding

Epidemiology of coronary artery disease among people with HIV in rural sub-Saharan AfricaR01HL141053 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2018 to 2021
$3.0M
Integrating HIV and hEART health in South Africa (iHeart-SA)UG3HL156388 · NHLBI · WITS HEALTH CONSORTIUM (PTY), LTD · PI ALI, MOHAMMED KUMAIL, MARCONI, VINCENT CHARLES · 2020 to 2021
$1.7M
Preventing Weight Gain and Diabetes in People with HIV in South AfricaK23DK125162 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNE-GOEHLER, JENNIFER · 2020 to 2024
$986k
Implementation research for comprehensive cardiometabolic care in GuatemalaK23HL161271 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Clifford Flood · 2022 to 2026
$949k
NHLBI NIH HHS K23 HL161271NHLBI NIH HHS R01 HL141053NHLBI NIH HHS UG3 HL156388NHLBI NIH HHS UG3HL156388NIDDK NIH HHS K23125162NIDDK NIH HHS K23 DK125162NIH HHS
6 · The paper itself

Abstract

The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) study found a 35% reduction in major adverse cardiovascular events for people with human immunodeficiency virus who received daily pitavastatin. However, how this evidence will change practice is far from certain. Here, we outline evidence gaps and political and healthcare delivery challenges that will need to be addressed for REPRIEVE to offer public health benefits in low- and middle-income countries.

Indexed as

Developing CountriesHIV InfectionsCardiovascular DiseasesHumansQuinolinesRandomized Controlled Trials as TopicpitavastatinQuinolinescardiovascular diseaseHIVintegrated care

Identifiers

PMID38066673
PMCPMC11175662
OpenAlexW4389514613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.