Evidence map›Paper›PMID 38066658›Full record

ArticleJournal of eating disorders2023

Randomised controlled trial of neurostimulation for symptoms of anorexia nervosa (TRENA study): study protocol.

Anna J Harvey, Sloane Madden, Anthony Rodgers, Michael Bull, Mary Lou Chatterton, Dusan Hadzi-Pavlovic, Colleen K Loo, Donel M Martin

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of eating disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05788042 (Randomised Controlled Trial of Neurostimulation for Symptoms of Anorexia Nervosa), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05788042 narecruitingnot on this map

Randomised Controlled Trial of Neurostimulation for Symptoms of Anorexia Nervosa

TypeinterventionalSponsorThe George InstituteRan2023 to 2026Enrolled70ConditionsAnorexia NervosaArmsMagPro TMS device (ARTG: 204659), tDCS mini-CT Stimulator (Soterix, USA: ARTG: 284637)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Anna J HarveyUniversity of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-4723-1933
Sloane MaddenRamsay Clinic Northside, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-5903-6647
Anthony RodgersThe George Institute for Global Health, Sydney, NSW, Australia.
Michael BullRamsay Clinic Northside, Sydney, NSW, Australia.
Mary Lou ChattertonMonash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-4902-9448
Dusan Hadzi-PavlovicUniversity of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-2059-3865
Colleen K LooUniversity of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-3267-0554
Donel M MartinUniversity of New South Wales, Sydney, NSW, Australia. donel.martin@unsw.edu.au.ORCID http://orcid.org/0000-0002-8452-0390
Black Dog Institute · AUMonash University · AUThe George Institute for Global Health · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnorexia nervosa (AN) has amongst the highest mortality rates and the highest treatment costs of any psychiatric disorder. Recently, interest in non-invasive brain stimulation as a novel treatment for AN has grown. These include repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS).

methodsThis double-blind, randomised sham-controlled trial will compare the relative acceptability and efficacy of tDCS and rTMS in people with AN. 70 participants will be randomised to active or sham tDCS, or active or sham rTMS treatment (2:1:2:1 ratio) over an 8-week treatment period. Participants will receive treatment as usual across the study duration. The primary outcomes are change on the Eating Disorder Examination Questionnaire and treatment acceptability. Secondary outcomes will include change in weight, cognition, mood, interpersonal functioning, and quality of life. Following the 8-week assessment, all participants will have the option of receiving an additional 12 weeks of at-home tDCS. A follow-up assessment will be conducted at 20 weeks post treatment. DISCUSSION: Research into non-invasive brain stimulation as treatments for AN has potential to improve clinical outcomes for patients by comparing the relative efficacy and acceptability of both treatment modalities in the inpatient and at-home setting (i.e., for at-home tDCS) results from this study will provide important information for informing future larger clinical trials of these treatments for AN.

trial registrationClinicalTrials.gov Identifier: NCT05788042.

Indexed as

Anorexia nervosaEating disorderRepetitive transcranial magnetic stimulationTranscranial direct current stimulation

Identifiers

PMID38066658
PMCPMC10709845
OpenAlexW4389488388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.