Evidence map›Paper›PMID 38066561›Full record

ArticleMolecular autism2023

Is the association between mothers' autistic traits and childhood autistic traits moderated by maternal pre-pregnancy body mass index?

Novika Purnama Sari, Alexandros Tsompanidis, Rama J Wahab, Romy Gaillard, Ezra Aydin, Rosemary Holt, Carrie Allison, Simon Baron-Cohen, Marinus H van IJzendoorn, Pauline W Jansen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular autism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Novika Purnama SariDepartment Psychology, Education & Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands. purnamasari@essb.eur.nl.
Alexandros TsompanidisDepartment of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK. at768@medschl.cam.ac.uk.
Rama J WahabGeneration R Study Group, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Romy GaillardDepartment of Child & Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Ezra AydinVagelos College of Physicians and Surgeons, Columbia University, New York, USA.
Rosemary HoltDepartment of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK.
Carrie AllisonDepartment of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK.
Simon Baron-CohenDepartment of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK.
Marinus H van IJzendoornDepartment Psychology, Education & Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Pauline W JansenDepartment Psychology, Education & Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Erasmus University Rotterdam · NLUniversity of Cambridge · GBColumbia University · USUniversity College London · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundPrevious studies showed that there is a positive association between mothers' and children's autistic traits. We also tested if this association is more pronounced in mothers with a higher pre-pregnancy body mass index (BMI).

methodThe study was embedded in two cohorts with information available for 4,659 participants from the Generation R and for 179 participants from the Cambridge Ultrasound Siblings and Parents Project (CUSP) cohort. In both cohorts, maternal autistic traits were assessed using the short form of the Autism Spectrum Quotient, and information about maternal height and weight before pregnancy was obtained by questionnaire. Child autistic traits were assessed with the short form of Social Responsiveness Scale in Generation R (M = 13.5 years) and with the Quantitative Checklist for Autism in Toddlers (Q-CHAT) in the CUSP cohort (M = 1.6 years).

resultHigher maternal autistic traits were associated with higher autistic traits in toddlerhood (CUSP cohort; β

conclusionWe confirm the association between maternal and child autistic traits in toddlerhood, early childhood, and early adolescence. Potential interacting neurobiological processes remain to be confirmed.

Indexed as

Autistic DisorderAdolescentBody Mass IndexChild, PreschoolFemaleHumansMothersParentsPregnancyAutistic traitsChildrenMothersPre-pregnancy body mass index

Identifiers

PMID38066561
PMCPMC10709910
OpenAlexW4389489674

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.