Genes polymorphism as risk factor of recurrent urolithiasis: a systematic review and meta-analysis.

Nur Rasyid, Soefiannagoya Soedarman

Open access · goldAbstract readMeta-AnalysisSystematic Review

In one paragraph

Synthesis in BMC nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 33% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Association between calcium-Sensing receptor gene polymorphisms and urinary calcium stone formation in the Han Chinese population from a High-Altitude region (Kunming) in China.Urolithiasis · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nur RasyidDepartment of Urology, Faculty of Medicine, Cipto Mangunkusumo Hospital, University, Jakarta Pusat, Indonesia. nur.rasyid2111@gmail.com.

Soefiannagoya SoedarmanDepartment of Urology, Faculty of Medicine, Cipto Mangunkusumo Hospital, University, Jakarta Pusat, Indonesia.

Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo · ID

Funding

PUTI Saintekes 2020 PUTI Saintekes 2020

6 · The paper itself

Abstract

introductionUrolithiasis is one of the most prevalent diseases worldwide. Its prevalence is rising, both in developing and developed countries. It is known that genetic factors play big roles in the development of urolithiasis. One of the suspected factors is gene polymorphism. This study aims to find an accurate estimate of the association between genetic polymorphism and the risk of recurrent urolithiasis.

methodsA systematic review and meta-analysis were performed on 12 studies from 3 databases that investigated gene polymorphism as an risk factor of urolithiasis. The review was done using Review Manager® version 5.3.

resultsInsignificant heterogenicity was found in this study. Populations from Asia and the Middle East are more likely to experience recurrent urolithiasis. Additionally, variation in the VDR and urokinase genes, particularly in the Asian population, increases the risk of developing recurrent urolithiasis.

conclusionsGene polymorphisms have significant roles in the development of urolithiasis, especially in the Middle Eastern region.

Indexed as

Polymorphism, GeneticUrolithiasisCase-Control StudiesDatabases, FactualGenetic Predisposition to DiseaseHumansRisk FactorsGene polymorphismGeneticSingle nucleotide polymorphismsUrolithiasis

Identifiers

PMID38066480

DOI10.1186/s12882-023-03368-y

PMCPMC10709856

OpenAlexW4389478095

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.