ArticleNature microbiology2024
BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility.
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Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
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44 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Cuproptosis and ferroptosis: signal pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Mechanisms underlying propagation of ferroptotic cell death.Nature cell biology · 2026Review
- Role of PRMT5 in regulating ferritinophagy during Mycobacterium tuberculosis infection.PLoS pathogens · 2026Article
- IFN𝛾 and IFN𝛾 mimetics prevent IFN-I-mediated TB susceptibility by regulating iron metabolism and lipid peroxidation.bioRxiv : the preprint server for biology · 2026Article
- Development of a high-throughput screening platform for identification of functional BACH1 inhibitors reveals compounds with anti-invasive potential.Redox biology · 2026Article
- NRF2-mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection.Cell reports · 2026Article
- Characterization of programmed cell death pathways activated in Mycobacterium tuberculosis-infected human macrophages.Cell death discovery · 2026Article
- Modulation of Ferroptosis During EarlybioRxiv : the preprint server for biology · 2026Article
- CD39 regulates P2RX7-mediated lung necrotic lesions in severe experimental tuberculosis.Mucosal immunology · 2026Article
- Mycobacterium tuberculosis-induced PCBP1 degradation drives macrophage ferroptosis to promote infection: a lung-macrophage-targeted RNAa nanotherapy.Journal of nanobiotechnology · 2026Article
- Rv1983 promotes mycobacterial dissemination by triggering ferroptosis through GPX4 ubiquitination.Cellular & molecular biology letters · 2026Article
- Elimination of senescent cells with senolytic drugs as adjunctive host-directed therapy reduces tuberculosis progression in mice.Nature communications · 2026Article
- Regulatory interplay between nitric oxide and heme in redox signaling and inflammation.Redox biology · 2026Review
- Macrophage adaptation to hypoxia in the tuberculous granuloma potentiates mycobacterium-induced mitochondrial damage and granuloma necrosis.bioRxiv : the preprint server for biology · 2026Article
- Piezo1 activation in endothelial cells aggravates microvascular ischemia-reperfusion injury in limbs by enhancing ferroptosis.Experimental & molecular medicine · 2026Article
- Recent progress in understanding ferroptosis mechanisms in infectious diseases.Frontiers in cellular and infection microbiology · 2026Review
- Necro-mosaic: a lesion-aware framework for testing programmed cell-death-associated mechanisms in tuberculosis.Frontiers in immunology · 2026Review
- Inflammasome Activation Differences Underpin DifferentMedComm · 2025Article
- Mycobacterium tuberculosis biology, pathogenicity and interaction with the host.Nature reviews. Microbiology · 2025Review
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Authors and funding
26 authors at 10 institutions in 5 countries.
Eduardo P AmaralImmunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA. eduardo.amaral@nih.gov.ORCID 0000-0001-5465-8113
Sivaranjani NamasivayamImmunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0001-9993-1347
Artur T L QueirozLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil.ORCID 0000-0003-4908-9993
Eduardo FukutaniLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil.
Kerry L HilliganImmunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0003-1238-1552
Kate AbermanImmunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.
Logan FisherImmunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0003-4680-1527
Caio Cesar B BomfimImmunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0003-1998-9237
Keith KauffmanT lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7208-1565
Jay BuchananT lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Leslie SantuoT lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Pedro Henrique Gazzinelli-GuimaraesHelminth Immunology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4932-2206
Diego L CostaImmunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0002-9440-2814
Mariane Araujo TeixeiraMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil.
Beatriz Barreto-DuarteLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil.
Clarissa Gurgel RochaDepartment of Pathology, School of Medicine of the Federal University of Bahia, Salvador, Bahia, Brazil.ORCID 0000-0001-8922-2985
Monique Freire SantanaDepartmento de Ensino e Pesquisa, Fundação Centro de Controle de Oncologia do Estado do Amazonas-FCECON, Manaus, Amazonas, Brazil.
Marcelo Cordeiro-SantosFundação Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas, Brazil.ORCID 0000-0002-7140-7145
Daniel L BarberT lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7008-7509
Robert J WilkinsonWellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-2753-1800
Igor KramnikBoston University School of Medicine, Boston, MA, USA.ORCID 0000-0001-6511-9246
Kazuhiko IgarashiDepartment of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID 0000-0002-2470-2475
Thomas ScribaSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Observatory, South Africa.ORCID 0000-0002-0641-1359
Katrin D Mayer-BarberInflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0002-0311-3233
Bruno B AndradeLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil.ORCID 0000-0001-6833-3811
Alan SherImmunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA. asher@niaid.nih.gov.ORCID 0000-0001-7053-2895
National Institutes of Health · USNational Institute of Allergy and Infectious Diseases · USFundação de Medicina Tropical · BRFundação Oswaldo Cruz · BRUniversidade Federal da Bahia · BRUniversity of Cape Town · ZACornell University · USTohoku University · JPUniversidade de Ribeirão Preto · BRUniversidade Salvador · BR
Funding
Immune Regulation in Mycobacterial InfectionsZIAAI001171 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARBER, DANIEL · 2012 to 2025
$16.7MInnate inflammatory responses during pulmonary infectionsZIAAI001207 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MAYER-BARBER, KATRIN · 2015 to 2025
$13.6MNecrosis in pulmonary TB granulomas: dynamics, mechanisms, therapiesR01HL126066 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KRAMNIK, IGOR, NIEDERWEIS, MICHAEL · 2016 to 2025
$5.6MTh2-associated responses and their control in parasitic helminth infections and related disordersZIAAI000805 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2024
$4.4MInflammatory determinants of disease severity and treatment outcome in TB patientsU01AI115940 · NIAID · UNIVERSITY OF CAPE TOWN · PI SHER, ALAN, WILKINSON, ROBERT JOHN · 2015 to 2019
$1.1MNHLBI NIH HHS R01 HL126066NIAID NIH HHS U01 AI115940Wellcome Trust CC2112
Abstract
Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) pathogenesis. We investigated whether Bach1, a transcription factor that represses multiple antioxidant genes, regulates host resistance to Mtb. We found that BACH1 expression is associated clinically with active pulmonary tuberculosis. Bach1 deletion in Mtb-infected mice increased glutathione levels and Gpx4 expression that inhibit lipid peroxidation. Bach1
Indexed as
Mycobacterium tuberculosisTuberculosisTuberculosis, PulmonaryAnimalsBasic-Leucine Zipper Transcription FactorsMacrophagesMiceNecrosisBach1 protein, mouseBasic-Leucine Zipper Transcription Factors
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