Evidence map›Paper›PMID 38066331›Full record

ArticleJournal of exposure science & environmental epidemiology2024

Annual space weather fluctuations and telomere length dynamics in a longitudinal cohort of older men: the Normative Aging Study.

Ting Zhai, Carolina L Zilli Vieira, Pantel Vokonas, Andrea A Baccarelli, Zachary D Nagel, Joel Schwartz, Petros Koutrakis

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ting ZhaiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.ORCID 0000-0002-8763-1387
Carolina L Zilli VieiraDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. cazilli@hsph.harvard.edu.
Pantel VokonasVA Normative Aging Study, Veterans Affairs Boston Healthcare System and the Department of Medicine, Boston University Chobanian and Avadisian School of Medicine, Boston, MA, 02115, USA.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, 10032, USA.
Zachary D NagelDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Petros KoutrakisDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Harvard University · USBoston University · USColumbia University · US

Funding

Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging CohortR01ES015172 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SCHWARTZ, JOEL D · 2006 to 2015
$4.8M
Multi-Pathway DNA Repair Capacity Measurements in Lung Cancer Patients and Healthy ControlsU01ES029520 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI CHRISTIANI, DAVID C, ENGELWARD, BEVIN P. · 2018 to 2022
$3.3M
Molecular and Epigenetic Mitochondriomics of Air Particles, Lead and CognitionR01ES021733 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2012 to 2015
$2.4M
Retrospective assessment of radon progeny and pollution effects in COPDR21ES029637 · NIEHS · HARVARD MEDICAL SCHOOL · PI GARSHICK, ERIC · 2019 to 2020
$453k
Air Pollution Exposure and Risk of Amyotrophic Lateral Sclerosis (ALS)R21ES028472 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIOUMOURTZOGLOU, MARIANTHI-ANNA · 2018 to 2019
$406k
Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention TrialR21ES021895 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2012 to 2013
$376k
EPA R835872NIEHS NIH HHS R01 ES015172NIEHS NIH HHS R01 ES021733NIEHS NIH HHS R21 ES021895NIEHS NIH HHS R21 ES028472NIEHS NIH HHS R21 ES029637NIEHS NIH HHS U01 ES029520
6 · The paper itself

Abstract

backgroundSpace weather has been associated with increased risk of cardiovascular diseases in space and flight crew. However, limited research has focused on the ground population, particularly among the elderly who are vulnerable to aging-related diseases.

objectiveWe evaluated the association between space weather alterations and biological aging using leukocyte telomere length as a biomarker in healthy elderly men.

methodsWe used data from the Normative Aging Study, a longitudinal cohort of healthy elderly men in Massachusetts, USA. Leukocyte telomere length and health information were measured at in-person examinations approximately every three years, contributing to a total of 1,850 visits from 791 participants. Regional space weather information was collected daily, including cosmic ray-induced ionization, neutrons, sunspot number, interplanetary magnetic field, and Kp-index as our exposure of interest. We used mixed-effects models with a random intercept per individual to evaluate the associations between annual averages of space weather indicators and relative telomere length while accounting for participant demographics, environmental parameters, and secular trends.

resultsThe mean age at baseline was 72.36 years. A one-year increment in age is associated with a 1.21% reduction in leukocyte telomere length. In the fully adjusted model accounting for individual and environmental factors, an interquartile range (IQR) increase of annual cosmic ray induced ionization (110.0 ion pairs cm IMPACT: Galactic cosmic rays may accelerate the aging process in populations on the Earth, despite the protection by the Earth's atmosphere and magnetic field. This research enhances our understanding of how changes in space weather can impact health, highlights potential risks from space to Earth's inhabitants, and helps inform health strategies for vulnerable populations.

Indexed as

AgingCosmic RadiationTelomereWeatherAgedAged, 80 and overCohort StudiesEnvironmental ExposureHumansLeukocytesLongitudinal StudiesMagnetic FieldsMaleMassachusettsEpidemiologyPopulation Based StudiesRadiationVulnerable Populations

Identifiers

PMID38066331
OpenAlexW4389476969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.