Evidence map›Paper›PMID 38066194›Full record

ArticleScientific reports2023

Rotavirus genotype diversity in Tanzania during Rotavirus vaccine implementation between 2013 and 2018.

Fausta Michael, Mariam M Mirambo, Dafrossa Lyimo, Abdul Salehe, Furaha Kyesi, Delfina R Msanga, Dina Mahamba, Helmut Nyawale, Elizabeth Kwiyolecha, Bernard Okamo and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Fausta MichaelMinistry of Health, Immunization and Vaccine Development Program, Dodoma, Tanzania.
Mariam M MiramboDepartment of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania. mmmirambo@gmail.com.
Dafrossa LyimoMinistry of Health, Immunization and Vaccine Development Program, Dodoma, Tanzania.
Abdul SaleheMinistry of Health, Immunization and Vaccine Development Program, Zanzibar, Tanzania.
Furaha KyesiMinistry of Health, Immunization and Vaccine Development Program, Dodoma, Tanzania.
Delfina R MsangaDepartment of Paediatrics and Child Health, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Dina MahambaDepartment of Pediatrics and Child Health, College of Health Sciences, University of Dodoma, P.O. Box 395, Dodoma, Tanzania.
Helmut NyawaleDepartment of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Elizabeth KwiyolechaDepartment of Paediatrics and Child Health, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Bernard OkamoDepartment of Biochemistry and Molecular Biology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Paul J MwanyikaDepartment of Pediatrics and Child Health, Mbeya Zonal Referral Hospital, P.O. Box 419, Mbeya, Tanzania.
Victoria MaghinaDepartment of Pediatrics and Child Health, Mbeya Zonal Referral Hospital, P.O. Box 419, Mbeya, Tanzania.
Elice BenderaDepartment of Pediatrics and Child Health, Muheza Designated District Hospital, Tanga, Tanzania.
Mohammed SaleheDepartment of Pediatrics and Child Health, Bombo Regional Referral Hospital, Tanga, Tanzania.
Adolfine HokororoDepartment of Paediatrics and Child Health, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Ernestina MwipopoDepartment of Pediatrics and Child Health, Mwananyamala Regional Referral Hospital, Dar es Salaam, Tanzania.
Asha C KhamisDepartment of Pediatrics and Child Health, Temeke Regional Referral Hospital, Dar es Salaam, Tanzania.
Honest NyakiMinistry of Health, Immunization and Vaccine Development Program, Dodoma, Tanzania.
Richard MagodiMinistry of Health, Immunization and Vaccine Development Program, Dodoma, Tanzania.
Delphius MujuniMinistry of Health, Immunization and Vaccine Development Program, Dodoma, Tanzania.
Eveline T KonjeDepartment of Epidemiology and Biostatistics, School of Public Health, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.
Betina KatemboNational Public Health Laboratory, Dar es Salaam, Tanzania.
Ritha WililloWorld Health Organization, Country Office, Dar es Salaam, Tanzania.
Stephen E MshanaDepartment of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.

Funding

World Health Organization 001
6 · The paper itself

Abstract

The study aims to determine Rotavirus genotypes between 2013 and 2018 during implementation of ROTARIX vaccine in Tanzania. The analysis of surveillance data obtained between 2013 and 2018 was done to determine circulating genotypes after introduction of Rotarix vaccine. From 2013 to 2018, a total of 10,557 samples were collected and screened for Rotavirus using an enzyme immunoassay. A significant decrease in Rotavirus positivity (29.3% to 17.8%) from 2013 to 2018 (OR 0.830, 95% CI 0.803-0.857, P < 0.001) was observed. A total of 766 randomly selected Rotavirus positive samples were genotyped. Between 2013 and 2018, a total of 18 Rotavirus genotypes were detected with G1P [8] being the most prevalent. The G1P [8] strain was found to decrease from 72.3% in 2015 to 13.5% in 2018 while the G9P [4] strain increased from 1 to 67.7% in the same years. G2P [4] was found to decrease from 59.7% in 2013 to 6.8% in 2018 while G3P [6] decreased from 11.2% in 2014 to 4.1% in 2018. The data has clearly demonstrated that ROTARIX vaccine has provided protection to varieties of the wild-type Rotavirus strains. Continuous surveillance is needed to monitor the circulation of Rotavirus strains during this era of vaccine implementation.

Indexed as

RotavirusRotavirus InfectionsRotavirus VaccinesFecesGenotypeHumansTanzaniaRotavirus Vaccines

Identifiers

PMID38066194
PMCPMC10709589

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.