Evidence map›Paper›PMID 38066108›Full record

ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2024

Insights into the complex interactions between Rab22a and extracellular vesicles in cancers.

Shenghao Huang, Yuxuan Bao, Lingjie Kong, Sheng Gao, Chunyan Hua

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shenghao HuangSchool of the 2nd Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Yuxuan BaoSchool of the 2nd Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Lingjie KongSchool of the 2nd Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Sheng GaoLaboratory Animal Center, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. 4869335@qq.com.
Chunyan HuaSchool of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. huachunyan@wmu.edu.cn.
Wenzhou Medical University · CN

Funding

National Natural Science Foundation of China 81901660Natural Science Foundation of Zhejiang Province LTGY23H100001Science and Technology Plan Project of Wenzhou, China Y20220045Science and Technology Plan Project of Wenzhou, China Y20220389
6 · The paper itself

Abstract

introductionOncogenic Ras-related GTP-binding proteins, referred to as Rabs, are characterized by their intricate interactions with upstream, downstream molecules, and notably, extracellular vesicles (EVs). While the expansive family of Rabs and their associated signaling pathways have been exhaustively dissected, Rab22a emerges as an entity of outstanding interest, owing to its potent influence in many biological processes and its conspicuous correlation with cancer metastasis and migration. A burgeoning interest in the interactions between Rab22a and EVs in the field of oncology underscores the necessity for more in-depth reviews and scholarly discourses.

methodsWe performed a review based on published original and review articles related to Rab22a, tumor, microRNA, exosome, microvesicles, EVs, CD147, lysosome, degradation, endosomal recycling, etc. from PubMed, Web of Science and Google Scholar databases. RESULTS AND

conclusionsWe summarize the regulatory processes governing the expression of Rab22a and the mutants of Rab22a. Notably, the present understanding of complex interactions between Rab22a and EVs are highlighted, encompassing both the impact of Rab22a on the genesis of EVs and the role of EVs that are affected by Rab22a mutants in propelling tumor advancement. The dynamic interaction between Rab22a and EVs plays a significant role in the progression of tumors, and it can provide novel insights into the pathogenesis of cancers and the development of new therapeutic targets.

Indexed as

Extracellular VesiclesMicroRNAsNeoplasmsEndosomesHumansrab GTP-Binding ProteinsMicroRNAsrab GTP-Binding ProteinsCancerExtracellular vesiclesRab22aRab GTPase

Identifiers

PMID38066108
OpenAlexW4389475049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.