ArticleOpen heart2023
BNP level predicts bleeding event in patients with heart failure after percutaneous coronary intervention.
Article in Open heart, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Development and External Validation of a Machine Learning-Based Bleeding Risk Score for Patients Undergoing Percutaneous Coronary Intervention.Circulation reports · 2026Article
- Bridging the Gut Microbiota and the Brain, Kidney, and Cardiovascular Health: The Role of Probiotics.Probiotics and antimicrobial proteins · 2026Review
- The impact of heart failure and bleeding risk on clinical outcomes in patients after percutaneous coronary intervention.BMC cardiovascular disorders · 2025Observational
- Long-term bleeding events post-percutaneous coronary intervention in patients with malignancy with and without anticoagulant therapy.Cardiovascular intervention and therapeutics · 2025Article
- Usefulness of the AHEAD score for prediction of all-cause death in patients with acute and chronic coronary syndromes.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Combining clinical markers can predict mortality in NYHA IV heart failure.Scientific reports · 2025Article
- Influencing factors analysis of clinical effect of heart failure patients treated with ivabradine and metoprolol succinate and construction and validation of nomogram prediction model.Frontiers in cardiovascular medicine · 2025Article
- Changes in systolic blood pressure during hospitalisation and bleeding events after percutaneous coronary intervention.Open heart · 2024Article
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Authors and funding
23 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to investigate the association between heart failure (HF) severity measured based on brain natriuretic peptide (BNP) levels and future bleeding events after percutaneous coronary intervention (PCI).
backgroundThe Academic Research Consortium for High Bleeding Risk presents a bleeding risk assessment for antithrombotic therapy in patients after PCI. HF is a risk factor for bleeding in Japanese patients.
methodsUsing an electronic medical record-based database with seven tertiary hospitals in Japan, this retrospective study included 7160 patients who underwent PCI between April 2014 and March 2020 and who completed a 3-year follow-up and were divided into three groups: no HF, HF with high BNP level and HF with low BNP level. The primary outcome was bleeding events according to the Global Use of Streptokinase and t-PA for Occluded Coronary Arteries classification of moderate and severe bleeding. The secondary outcome was major adverse cardiovascular events (MACE). Furthermore, thrombogenicity was measured using the Total Thrombus-Formation Analysis System (T-TAS) in 536 consecutive patients undergoing PCI between August 2013 and March 2017 at Kumamoto University Hospital.
resultsMultivariate Cox regression showed that HF with high BNP level was significantly associated with bleeding events, MACE and all-cause death. In the T-TAS measurement, the thrombogenicity was lower in patients with HF with high BNP levels than in those without HF and with HF with low BNP levels.
conclusionsHF with high BNP level is associated with future bleeding events, suggesting that bleeding risk might differ depending on HF severity.
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