Evidence map›Paper›PMID 38065141›Full record

ArticleThe Review of scientific instruments2023

A novel approach to expedite wound healing with plasma brush of cold flame.

Qing Hong, Xiaoqing Dong, John E Jones, Liang Hong, Qingsong Yu, Hongmin Sun, Meng Chen

Open access · greenAbstract read
In one paragraph

Article in The Review of scientific instruments, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. [Mechanism of cold atmospheric plasma in treatment of chronic skin ulcer].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Qing HongDepartment of Mechanical and Aerospace Engineering, University of Missouri, Columbia, Missouri 65211, USA.ORCID 0000-0002-2253-4439
Xiaoqing DongNanova, Inc., Columbia, Missouri 65202, USA.
John E JonesNanova, Inc., Columbia, Missouri 65202, USA.ORCID 0000-0001-5772-6855
Liang HongDepartment of Pediatric Dentistry and Community Oral Health, College of Dentistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.ORCID 0000-0003-3006-1907
Qingsong YuDepartment of Mechanical and Aerospace Engineering, University of Missouri, Columbia, Missouri 65211, USA.ORCID 0000-0002-6985-5969
Hongmin SunDivision of Cardiovascular Medicine, Department of Medicine, University of Missouri, Columbia, Missouri 65212, USA.ORCID 0000-0003-4545-2417
Meng ChenNanova, Inc., Columbia, Missouri 65202, USA.ORCID 0000-0001-9098-9518
Nanova Biomaterials (United States) · USUniversity of Missouri · USUniversity of Tennessee Health Science Center · US

Funding

Development of a Miniature Plasma Brush for Dental Clinical ApplicationsR44DE019041 · NIDCR · NANOVA, INC. · PI CHEN, MENG · 2010 to 2012
$1.5M
NIDCR NIH HHS R44 DE019041
6 · The paper itself

Abstract

Excessive or persistent infection is a major contributing factor in impeding chronic wound healing. Wound bed preparations using antiseptics do not necessarily target the entire bacterial spectrum, and the highly proliferating granulation tissue may be sensitive to the cytotoxic effects, impairing tissue repair. Non-thermal gas atmospheric pressure plasmas are partially ionized gases that contain highly reactive particles while the gas phase remains near room temperature, thus having the capability of accessing small irregular cavities and fissures and killing bacteria because of the diffusive nature of gas phase plasma species that are chemically reactive, providing an ideal approach to topical wound disinfection. A non-thermal plasma brush device of novel design has been developed that is suitable for clinical application in the disinfection of oral and wound bacteria. In vivo studies have indicated that the plasma brush treatment rendered no harmful effect on healthy skin or tissues, while it could improve wound healing in Pseudomonas aeruginosa biofilm infected wounds exposed to an optimized treatment with argon plus 1% nitrogen (Ar + N2) plasma.

Indexed as

Plasma GasesBacteriaNitrogenSkinWound HealingNitrogenPlasma Gases

Identifiers

PMID38065141
PMCPMC10431944
OpenAlexW4385841148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.