ArticleProceedings of the National Academy of Sciences of the United States of America2023
ALS-linked C9orf72-SMCR8 complex is a negative regulator of primary ciliogenesis.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 9 citations in OpenAlex.
- Review
- The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair.The EMBO journal · 2026Article
- The Activation of ARF1 Is Dynamically Regulated by its Palmitoylation.Molecular & cellular proteomics : MCP · 2026Article
- Pathophysiological significance of cholesterol in ciliopathies.Fujita medical journal · 2026Article
- Superoxide dismutase impacts extracellular vesicle shedding and uptake.Free radical biology & medicine · 2026Article
- Aberrant CDK4/6-driven cell-cycle reentry drives neuronal loss and defines a therapeutic target in C9orf72 ALS/FTD.iScience · 2026Article
- Linking primary cilia defects to the "Big 3" neurodegenerative diseases - causal, consequential, or correlative?EXCLI journal · 2026Article
- Primary Cilia Formation Mediated by Hsa_Circ_0005185/OTUB1/RAB8A Complex Inhibits Prostate Cancer Progression by Suppressing Hedgehog Signaling Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Emerging roles of primary cilia in the pathogenesis of amyotrophic lateral sclerosis.Frontiers in neuroscience · 2025Review
- NEK1 haploinsufficiency worsens DNA damage, but not defective ciliogenesis, in C9ORF72 patient-derived iPSC-motoneurons.Human molecular genetics · 2024Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 3 institutions in 2 countries.
Dan Tang *Department of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.ORCID 0009-0006-0986-9767
Kaixuan Zheng *Department of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Jiangli Zhu *Department of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.ORCID 0000-0002-7467-4484
Xi Jin *Department of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Hui Bao *Department of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Lan Jiang *Department of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Huihui LiDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.ORCID 0000-0001-6004-3086
Yichang WangDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Ying LuDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Jiaming LiuDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Hang LiuDivision of Life Science, Center of Systems Biology and Human Health, The Hong Kong University of Science and Technology, Kowloon, Hong Kong Special Administrative Region, People's Republic of China.ORCID 0000-0002-6176-3963
Chengbing TangDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Shijian FengDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Xiuju DongDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Liangting XuDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.ORCID 0000-0002-9168-0931
Yike YinDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.ORCID 0000-0002-2899-3329
Shangyu DangDivision of Life Science, Center of Systems Biology and Human Health, The Hong Kong University of Science and Technology, Kowloon, Hong Kong Special Administrative Region, People's Republic of China.ORCID 0000-0001-9141-1865
Xiawei WeiLaboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
Haiyan RenDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.ORCID 0000-0001-9995-3255
Biao DongLaboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
Lunzhi DaiDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.ORCID 0000-0002-3003-8910
Wei ChengDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Meihua WanDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Zhonghan LiDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.ORCID 0000-0001-5752-3417
Jing ChenDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Hong LiDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Eryan KongInstitute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang 453000, People's Republic of China.ORCID 0000-0002-4086-1441
Kunjie WangDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.
Kefeng LuDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.ORCID 0000-0001-8200-9380
Shiqian QiDepartment of Urology, Institute of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, and National Collaborative Innovation Center, Chengdu 610041, People's Republic of China.ORCID 0000-0002-7589-8877
Sichuan University · CNHong Kong University of Science and Technology · HKXinxiang Medical University · CN
Funding
MOST | National Natural Science Foundation of China (NSFC) 31970693MOST | National Natural Science Foundation of China (NSFC) 32022020MOST | National Natural Science Foundation of China (NSFC) 32071214MOST | National Natural Science Foundation of China (NSFC) 32201025the 135 Project for Disciplines of Excellence, West China Hospital, Sichuan University ZYGD18011the 135 Project for Disciplines of Excellence, West China Hospital, Sichuan University ZYJC18015the 135 Project for Disciplines of Excellence, West China Hospital, Sichuan University ZYYC20015the 135 Project for Disciplines of Excellence, West China Hospital, Sichuan University ZYYC20016the Fundamental Research Funds for the Central Universities 2022SCU12041the Natural Science Foundation of Sichuan, China 2022NSFSC0049
Abstract
Massive GGGGCC (G4C2) repeat expansion in
Indexed as
Amyotrophic Lateral SclerosisC9orf72 ProteinCiliaFrontotemporal DementiaAnimalsCarrier ProteinsDNA Repeat ExpansionGTPase-Activating ProteinsHEK293 CellsHumansMiceC9orf72 ProteinCarrier ProteinsGTPase-Activating ProteinsSMCR8 protein, humanSMCR8 protein, mouseC9orf72GAPmembrane traffickingprimary ciliumSMCR8
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LicenceCC BY-NC-ND
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.