Evidence map›Paper›PMID 38064513›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Dopamine D2 receptors in hilar mossy cells regulate excitatory transmission and hippocampal function.

Michelle C Gulfo, Joseph J Lebowitz, Czarina Ramos, Dong-Woo Hwang, Kaoutsar Nasrallah, Pablo E Castillo

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  8. Dopamine D2 receptors in hilar mossy cells regulate excitatory transmission and hippocampal function.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michelle C GulfoDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0003-1308-5982
Joseph J LebowitzVollum Institute, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0002-2923-7103
Czarina RamosDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
Dong-Woo HwangDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0001-5806-067X
Kaoutsar NasrallahDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0002-2627-7417
Pablo E CastilloDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0002-9834-1801
Albert Einstein College of Medicine · USOregon Health & Science University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
BIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4M
Mechanism of MRNA Localization and Localized Translation in NeuronsR01NS083085 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Sulagna Das, Robert H Singer · 2013 to 2026
$9.0M
COCAINE: EFFECTS ON SINGLE NEURONSR01DA004523 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1987 to 2025
$7.6M
Medical Scientist Training ProgramT32GM149364 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Myles H. Akabas · 2023 to 2026
$7.5M
Presynaptic forms of long-term plasticity in the CNSR01MH125772 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI PABLO E CASTILLO · 2020 to 2026
$3.6M
Synaptic Mechanisms for Contextual Memory FormationR01MH116673 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI CASTILLO, PABLO E, LIN, YINGXI · 2019 to 2023
$3.4M
Activity-Dependent Transcriptional Pathways Underlying Synaptic Mechanisms for Memory Discrimination and Generalization.R01NS115543 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI CASTILLO, PABLO E, LIN, YINGXI · 2020 to 2024
$3.0M
Activity-Dependent Plasticity in an Associative Hippocampal Circuit: Mechanisms, Synaptic Learning Rules and Involvement in DiseaseR01NS113600 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI CASTILLO, PABLO E · 2019 to 2023
$2.7M
Following mRNA from birth to death at single-molecule resolutionR35GM136296 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SINGER, ROBERT H · 2020 to 2024
$2.3M
Zeiss Confocal Microscope with Airyscan for Einstein Neural Cell Engineering and Imaging CoreS10OD025295 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DOBRENIS, KOSTANTIN · 2019 to 2019
$523k
Activity Dependent Changes in the Contextual Memory EngramF31MH127910 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI RAMOS, CZARINA · 2021 to 2024
$143k
NIDA NIH HHS R01 DA004523NIDA NIH HHS T32 DA007262NIGMS NIH HHS R35 GM136296NIGMS NIH HHS T32 GM007288NIGMS NIH HHS T32 GM149364NIH HHS S10 OD025295NIMH NIH HHS F31 MH122134NIMH NIH HHS F31 MH127910NIMH NIH HHS R01 MH116673NIMH NIH HHS R01 MH125772NINDS NIH HHS R01 NS083085NINDS NIH HHS R01 NS113600NINDS NIH HHS R01 NS115543
6 · The paper itself

Abstract

Hilar mossy cells (MCs) are principal excitatory neurons of the dentate gyrus (DG) that play critical roles in hippocampal function and have been implicated in brain disorders such as anxiety and epilepsy. However, the mechanisms by which MCs contribute to DG function and disease are poorly understood. A defining feature of MCs is the promoter activity of the dopamine D2 receptor (D2R) gene (

Indexed as

EpilepsyMossy Fibers, HippocampalReceptors, Dopamine D2AnimalsAnxietyDentate GyrusDopamineHippocampusMiceDopamineDRD2 protein, mouseReceptors, Dopamine D2dentate gyrusdopaminehippocampusmemorymossy cell

Identifiers

PMID38064513
PMCPMC10723153
OpenAlexW4389474974

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.