ArticlePloS one2023
Age-related changes in dermal collagen physical properties in human skin.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of hydrolyzed collagen supplementation on skin health outcomes: a systematic literature review of randomized controlled trials.European journal of clinical nutrition · 2026Pooled it
- Age-Associated Differences in Facial Skin Structure in Chinese Women: a Cross-Sectional Study.Dermatology and therapy · 2026Article
- Natural Histidine Derivatives-From Basic Research to Potential Applications in Cosmetics and Nutricosmetics.Antioxidants (Basel, Switzerland) · 2026Review
- Review
- From ECM Aging to Mechanobiological Restoration: Injectable Fillers and Dermal Fibroblast Mechanotransduction-A Narrative Review.Gels (Basel, Switzerland) · 2026Review
- Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.Nutrients · 2026Review
- Integrating serial block-face SEM with voxel-based finite element analysis for high-fidelity micromechanical modelling of anisotropic soft tissues: application to human dermis.Biomechanics and modeling in mechanobiology · 2026Article
- Effect of Gelatin-Peptide Complex from Sturgeon Skin on Behavioral, Antioxidant, and Neuroprotective Functions in D-Galactose-Induced Aging Mice: Thermal Degradation vs. Enzymatic Hydrolysis.Foods (Basel, Switzerland) · 2026Article
- Imageomics defines granular morphological changes of human skin with age and reveals a rejuvenating effect of xenografting.bioRxiv : the preprint server for biology · 2026Article
- Correlation Between Advanced Glycation End Products and Ultrasonographic Measurements of Cervico-Facial Skin Tissue.Diagnostics (Basel, Switzerland) · 2026Article
- Regenerative Therapies for Cosmetic Dermatology for Patients with Diabetes Mellitus: Skin Aging, Aesthetic Concerns, and Evidence-Based Best Practices.International journal of molecular sciences · 2026Review
- Article
- Ultrastructural Analysis of In Vitro Glycated Engineered Skin.Journal of cosmetic dermatology · 2026Article
- Remodeling Effect of HA Hybrid Cooperative Complexes on Dermal White Adipose Tissue and Its Structure.Clinical, cosmetic and investigational dermatology · 2026Article
- Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism.Journal of cosmetic dermatology · 2026Article
- The Tripartite Regulatory Framework of the Skin Extracellular Microenvironment and Related Anti-aging Strategies.Mini reviews in medicinal chemistry · 2026Review
- Atelocollagen Increases Collagen Synthesis by Promoting Glycine Transporter 1 in Aged Mouse Skin.International journal of molecular sciences · 2025Article
- In Vitro Bioactivity of a Recombinant Human Collagen Peptide in a Filler Biomimetic Skin Model.Journal of cosmetic dermatology · 2025Article
- Age-Related Variations in Reoperation Risk from Suture Loosening in Two-Point Buried Suture Double Eyelid Surgery: A Stratified Retrospective Cohort Analysis.Aesthetic plastic surgery · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Collagen is the major structural protein in the skin. Fragmentation and disorganization of the collagen fibrils are the hallmarks of the aged human skin dermis. These age-related alterations of collagen fibrils impair skin structural integrity and make the tissue microenvironment more prone to skin disorders. As the biological function of collagen lies predominantly in its physical properties, we applied atomic force microscopy (AFM) and nanoindentation to evaluate the physical properties (surface roughness, stiffness, and hardness) of dermal collagen in young (25±5 years, N = 6) and aged (75±6 years, N = 6) healthy sun-protected hip skin. We observed that in the aged dermis, the surface of collagen fibrils was rougher, and fiber bundles were stiffer and harder, compared to young dermal collagen. Mechanistically, the age-related elevation of matrix metalloproteinase-1 (MMP-1) and advanced glycation end products (AGEs) are responsible for rougher and stiffer/harder dermal collagen, respectively. Analyzing the physical properties of dermal collagen as a function of age revealed that alterations of the physical properties of collagen fibrils changed with age (22-89 years, N = 18). We also observed that the reticular dermis is rougher and mechanically stiffer and harder compared to the papillary dermis in human skin. These data extend the current understanding of collagen beyond biological entities to include biophysical properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.