Evidence map›Paper›PMID 38064281›Full record

ArticleClinical transplantation2024

The liver frailty index is a predictor of healthcare utilization after liver transplantation in older adults.

Melinda Wang, Amy M Shui, Jessica Ruck, Elizabeth King, Robert Rahimi, Matthew Kappus, Michael L Volk, Daniel R Ganger, Daniela P Ladner, Andres Duarte-Rojo and 3 more

Abstract read
In one paragraph

Article in Clinical transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Tumor burden and frailty: No association in liver transplantation candidates with hepatocellular carcinoma.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026
    Article
  3. Observational
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Melinda WangDepartment of Medicine, University of California- San Francisco, San Francisco, California, USA.ORCID 0000-0002-1305-8362
Amy M ShuiDepartment of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, California, USA.
Jessica RuckDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Elizabeth KingDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Robert RahimiDivision of Gastroenterology and Hepatology, Department of Medicine, Baylor Scott and White Health, Dallas, Texas, USA.
Matthew KappusDivision of Gastroenterology, Department of Medicine, Duke University Hospital, Durham, North Carolina, USA.
Michael L VolkDivision of Gastroenterology and Nutrition, Department of Medicine, Loma Linda University, Loma Linda, California, USA.
Daniel R GangerDivision of Gastroenterology and Nutrition, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Daniela P LadnerDivision of Organ Transplantation, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Andres Duarte-RojoDivision of Gastroenterology and Hepatology, Department of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0002-5377-9295
Chiung-Yu HuangDepartment of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, California, USA.
Elizabeth C VernaCenter for Liver Division of Digestive and Liver Diseases, Diseases and Transplantation, Columbia University Medical Center, New York, New York, USA.
Jennifer C LaiDivision of Gastroenterology and Hepatology, Department of Medicine, University of California-San Francisco, San Francisco, California, USA.ORCID 0000-0003-2092-6380

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
The spectrum of cognitive impairment including Alzheimer’s Disease and Related Dementias after liver transplantationR01AG059183 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2018 to 2026
$9.9M
Investigating the role of frailty on outcomes in acutely ill patients with cirrhosis undergoing liver transplantation in the acute care settingR01DK133527 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2023 to 2026
$2.9M
The Impact of Frailty on Liver Transplant Outcomes in Older Adults with Hepatocellular CarcinomaK24AG080021 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2023 to 2026
$755k
Frailty and post-liver transplant delirium and cognitive impairment in older recipientsF32AG067642 · NIA · JOHNS HOPKINS UNIVERSITY · PI RUCK, JESSICA MOORE · 2021 to 2023
$258k
NIA NIH HHS F32 AG067642NIA NIH HHS K24 AG080021NIA NIH HHS R01 AG059183NIDDK NIH HHS P30 DK026743NIDDK NIH HHS R01 DK133527
6 · The paper itself

Abstract

backgroundOlder adults have higher healthcare utilization after liver transplantation (LT), yet objective risk stratification tools in this population are lacking. We evaluated the Liver Frailty Index (LFI) as one potential tool.

methodsAmbulatory LT candidates ≥65 years without hepatocellular carcinoma (HCC) who underwent LT from 1/2012 to 6/2022 at 8 U.S. centers were included. Estimates of the difference in median using quantile regression were used to assess the adjusted association between LFI and hospitalized days within 90 days post-LT.

resultsOf 131 LT recipients, median (interquartile range [IQR]) (1

conclusionAmong older adults undergoing LT, frailty was associated with more hospitalized days within 90 days after LT. The LFI can identify older adults who might benefit from pre-LT or early post-LT programs which may reduce post-LT healthcare utilization, such as early rehabilitation or post-hospital discharge programs.

Indexed as

Carcinoma, HepatocellularFrailtyLiver NeoplasmsLiver TransplantationAgedHumansPatient Acceptance of Health Carefrailtyhealthcare utilizationhospital daysliver transplantolder

Identifiers

PMID38064281
PMCPMC11042074

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.