Evidence map›Paper›PMID 38064106›Full record

ArticleMolecular neurobiology2024

Association of Biochemical Parameters and Screening for Mutations in the MCU Gene in Alzheimer's Disease Patients.

Anila Venugopal, Mahalaxmi Iyer, Arul Narayanasamy, T Ravimanickam, Abilash Valsala Gopalakrishnan, Mukesh Kumar Yadav, Nachimuthu Senthil Kumar, Balachandar Vellingiri

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Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Anila VenugopalHuman Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, 641 046, Coimbatore, Tamil Nadu, India.
Mahalaxmi IyerCenter for Neuroscience, Department of Biotechnology, Karpagam Academy of Higher Education, 641 021, Coimbatore, Tamil Nadu, India.
Arul NarayanasamyDisease Proteomics Laboratory, Department of Zoology, Bharathiar University, 641046, Coimbatore, Tamil Nadu, India.
T RavimanickamDepartment of Zoology, School of Science, Tamil Nadu Open University, 600015, Chennai, Tamil Nadu, India.
Abilash Valsala GopalakrishnanDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology, Tamil Nadu, 632014, Vellore, India.
Mukesh Kumar YadavDepartment of Microbiology, School of Basic Sciences, Central University of Punjab, 151401, Bathinda, Punjab, India.
Nachimuthu Senthil KumarDepartment of Biotechnology, Mizoram University, 796004, Aizawl, Mizoram, India.
Balachandar VellingiriHuman Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, 641 046, Coimbatore, Tamil Nadu, India. balachandar.vellingiri@cup.edu.in.ORCID http://orcid.org/0000-0002-3043-6839
Bharathiar University · INCentral University of Punjab · INMizoram University · INTamil Nadu Open University · INVellore Institute of Technology University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most prevalent form of dementia, Alzheimer's disease (AD) is a chronic illness that is on the rise among the geriatric population. Even though research into its biochemical, genetic, and cytogenetic pathways has advanced, its aetiology is still unclear and complex. In this study, we recruited sixty-eight participants diagnosed with AD where the cytogenetic, biochemical parameters and genetic mutations were analysed. Our results revealed chromosomal aberrations such as aneuploidies in the peripheral blood of Alzheimer's disease patients. Biochemical parameters revealed no statistical significance in the study though a pattern could be observed in the serum levels. Further few novel mutations at the c.21 C > T, c.56G > A were observed in the MCU gene of mitochondrial calcium uniporter. All these findings reveal the need for a larger cohort study to gain a better and more detailed understanding of the aetiology of Alzheimer's disease.

Indexed as

Alzheimer DiseaseCalcium ChannelsMutationAgedAged, 80 and overFemaleGenetic Association StudiesHumansMaleMiddle AgedCalcium Channelsmitochondrial calcium uniporterAlzheimer’s DiseaseBiochemical ParametersCytogeneticsHormonesMCUMitochondrial Calcium Uniporter

Identifiers

PMID38064106
OpenAlexW4389486977

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.