Evidence map›Paper›PMID 38063930›Full record

ArticleThe ultrasound journal2023

Additional predictive value of optic nerve sheath diameter for neurological prognosis after cardiac arrest: a prospective cohort study.

Marlous M L H Verhulst, Iris M Visser, Hanneke M Keijzer, Nicole L M de Kruijf, Erwin J G Peters, Thom Wilbers, Roel V Peelen, Jeannette Hofmeijer, Michiel J Blans

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The ultrasound journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04084054 (Ultrasonic Measurement of the Optic Nerve Sheath Diameter Predicting Outcome After Cardiac Arrest), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04084054 unknown statusnot on this map

Ultrasonic Measurement of the Optic Nerve Sheath Diameter Predicting Outcome After Cardiac Arrest

TypeobservationalSponsorRijnstate HospitalRan2019 to 2023Enrolled160ConditionsPost-Anoxic ComaArmsUltrasound
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marlous M L H VerhulstDepartment of Neurology, Rijnstate Hospital, 6800 TA, Arnhem, The Netherlands. m.m.l.h.verhulst@utwente.nl.ORCID http://orcid.org/0000-0002-5025-5867
Iris M VisserTechnical Medicine, University of Twente, 7522NB, Enschede, The Netherlands.
Hanneke M KeijzerDepartment of Neurology, Rijnstate Hospital, 6800 TA, Arnhem, The Netherlands.
Nicole L M de KruijfDepartment of Neurology, Rijnstate Hospital, 6800 TA, Arnhem, The Netherlands.
Erwin J G PetersDepartment of Intensive Care Medicine, Rijnstate Hospital, 6800 TA, Arnhem, The Netherlands.
Thom WilbersDepartment of Intensive Care Medicine, Rijnstate Hospital, 6800 TA, Arnhem, The Netherlands.
Roel V PeelenDepartment of Intensive Care Medicine, Rijnstate Hospital, 6800 TA, Arnhem, The Netherlands.
Jeannette HofmeijerDepartment of Neurology, Rijnstate Hospital, 6800 TA, Arnhem, The Netherlands.
Michiel J BlansDepartment of Intensive Care Medicine, Rijnstate Hospital, 6800 TA, Arnhem, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe goal is to estimate the additional value of ultrasonographic optic nerve sheath diameter (ONSD) measurement on days 1-3, on top of electroencephalography (EEG), pupillary light reflexes (PLR), and somatosensory evoked potentials (SSEP), for neurological outcome prediction of comatose cardiac arrest patients. We performed a prospective longitudinal cohort study in adult comatose patients after cardiac arrest. ONSD was measured on days 1-3 using ultrasound. Continuous EEG, PLR, and SSEP were acquired as standard care. Poor outcome was defined as cerebral performance categories 3-5 at 3-6 months. Logistic regression models were created for outcome prediction based on the established predictors with and without ONSD. Additional predictive value was assessed by increase in sensitivity for poor (at 100% specificity) and good outcome (at 90% specificity).

resultsWe included 100 patients, 54 with poor outcome. Mean ONSD did not differ significantly between patients with good and poor outcome. Sensitivity for predicting poor outcome increased by adding ONSD to EEG and SSEP from 25% to 41% in all patients and from 27% to 50% after exclusion of patients with non-neurological death.

conclusionsONSD on days 1-3 after cardiac arrest holds potential to add to neurological outcome prediction.

trial registrationclinicaltrials.gov, NCT04084054. Registered 10 September 2019, https://www. CLINICALTRIALS: gov/study/NCT04084054 .

Indexed as

Cardiac arrestIntracranial pressureNeurological outcomeOptic nerve sheath diameterPrognosisUltrasound

Identifiers

PMID38063930
PMCPMC10709263

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