Evidence map›Paper›PMID 38063379›Full record

ArticlemBio2024

The streptococcal phase-variable type I restriction modification system SsuCC20p dictates the methylome of

Thomas J Roodsant, Boas van der Putten, Jaime Brizuela, Jordy P M Coolen, Tim J H Baltussen, Kim Schipper, Yvonne Pannekoek, Kees C H van der Ark, Constance Schultsz

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. How to Unmask an Unknown: The Restriction-Modification SystemInternational journal of molecular sciences · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Isolation of phages infecting the zoonotic pathogenbioRxiv : the preprint server for biology · 2025
    Article
  7. Antimicrobial resistance and mechanisms of epigenetic regulation.Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas J RoodsantDepartment of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0003-0553-8734
Boas van der PuttenDepartment of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-7916-6665
Jaime BrizuelaDepartment of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Jordy P M CoolenDepartment of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.ORCID 0000-0003-0443-6250
Tim J H BaltussenDepartment of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.ORCID 0000-0001-7038-9005
Kim SchipperDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Yvonne PannekoekDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0003-1154-652X
Kees C H van der ArkDepartment of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Constance SchultszDepartment of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Funding

EC | Horizon 2020 Framework Programme (H2020) 727966
6 · The paper itself

Abstract

importancePhase variation allows a single strain to produce phenotypic diverse subpopulations. Phase-variable restriction modification (RM) systems are systems that allow for such phase variation via epigenetic regulation of gene expression levels. The phase-variable RM system SsuCC20p was found in multiple streptococcal species and was acquired by an emerging zoonotic lineage of

Indexed as

Streptococcal InfectionsStreptococcus suisAnimalsBacterial ProteinsDNA Restriction-Modification EnzymesEpigenesis, GeneticEpigenomeLarvaTranscriptomeVirulenceZebrafishBacterial ProteinsDNA Restriction-Modification EnzymesDNA methylationepigenetic regulationphase-variationStreptococcus suistranscriptometype I restriction modification systemzoonosis

Identifiers

PMID38063379
PMCPMC10790761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.