Evidence map›Paper›PMID 38063308›Full record

ArticleACS applied bio materials2023

Cationic Porphyrin-Based Ionic Nanomedicines for Improved Photodynamic Therapy.

Mavis Forson, Mujeebat Bashiru, Samantha Macchi, Sarbjot Singh, Ashley Danyelle Anderson, Shehzad Sayyed, Arisha Ishtiaq, Robert Griffin, Nawab Ali, Adegboyega K Oyelere and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Mavis ForsonDepartment of Chemistry, University of Arkansas at Little Rock, 2801 S. University Ave, Little Rock, Arkansas 72204, United States.ORCID 0000-0002-3644-2199
Mujeebat BashiruDepartment of Chemistry, University of Arkansas at Little Rock, 2801 S. University Ave, Little Rock, Arkansas 72204, United States.ORCID 0000-0002-7947-5361
Samantha MacchiDepartment of Chemistry, University of Arkansas at Little Rock, 2801 S. University Ave, Little Rock, Arkansas 72204, United States.ORCID 0000-0002-7546-4200
Sarbjot SinghDepartment of Chemistry, University of Arkansas at Little Rock, 2801 S. University Ave, Little Rock, Arkansas 72204, United States.
Ashley Danyelle AndersonArkansas State Crime Laboratory, 3 Natural Resources Dr, Little Rock, Arkansas 72205, United States.
Shehzad SayyedDepartment of Biology, University of Arkansas, 1 University of Arkansas, Fayetteville, Arkansas 72701, United States.
Arisha IshtiaqDepartment of Chemistry, University of Arkansas at Little Rock, 2801 S. University Ave, Little Rock, Arkansas 72204, United States.
Robert GriffinDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Winthrop P. Rockefeller Cancer Institute, Arkansas Nanomedicine Center, 4301 W Markham St, Little Rock, Arkansas 72205, United States.
Nawab AliDepartment of Biology, University of Arkansas at Little Rock, 2801 S. University Ave, Little Rock, Arkansas 72204, United States.
Adegboyega K OyelereSchool of Chemistry and Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Brian BerryDepartment of Chemistry, University of Arkansas at Little Rock, 2801 S. University Ave, Little Rock, Arkansas 72204, United States.
Noureen SirajDepartment of Chemistry, University of Arkansas at Little Rock, 2801 S. University Ave, Little Rock, Arkansas 72204, United States.ORCID 0000-0003-4925-0265
University of Arkansas at Little Rock · USArkansas State Crime Laboratory · USGeorgia Institute of Technology · USUniversity of Arkansas at Fayetteville · USWinthrop Rockefeller Foundation · US

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
NIGMS NIH HHS P20 GM103429
6 · The paper itself

Abstract

This study presents the synthesis and characterization of monosubstituted cationic porphyrin as a photodynamic therapeutic agent. Cationic porphyrin was converted into ionic materials by using a single-step ion exchange reaction. The small iodide counteranion was replaced with bulky BETI and IR783 anions to reduce aggregation and enhance the photodynamic effect of porphyrin. Carrier-free ionic nanomedicines were then prepared by using the reprecipitation method. The photophysical characterization of parent porphyrin, ionic materials, and ionic nanomaterials, including absorbance, fluorescence and phosphorescence emission, quantum yield, radiative and nonradiative rate, and lifetimes, was performed. The results revealed that the counteranion significantly affects the photophysical properties of porphyrin. The ionic nanomaterials exhibited an increase in the reactive oxygen yield and enhanced cytotoxicity toward the MCF-7 cancer cell line. Examination of results revealed that the ionic materials exhibited an enhanced photodynamic therapeutic activity with a low IC

Indexed as

PhotochemotherapyPorphyrinsCationsHumansNanomedicinePhotosensitizing AgentsCationsPhotosensitizing AgentsPorphyrinscancer therapycytotoxicityionic materialsnanoparticlesorganic synthesissinglet oxygensubcellular localization

Identifiers

PMID38063308
PMCPMC10777306
OpenAlexW4389477219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.