Evidence map›Paper›PMID 38063246›Full record

ArticleCancer medicine2023

Hypoxia is correlated with the tumor immune microenvironment: Potential application of immunotherapy in bladder cancer.

Haotian Chen, Yao Zhang, Xingyu Chen, Runshi Xu, Yuxing Zhu, Dong He, YaXin Cheng, Zhanwang Wang, Xiang Qing, Ke Cao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Haotian ChenDepartment of Oncology, Third Xiangya Hospital, Central South University, Changsha, China.
Yao ZhangDepartment of Oncology, Third Xiangya Hospital, Central South University, Changsha, China.
Xingyu ChenDepartment of Oncology, Third Xiangya Hospital, Central South University, Changsha, China.
Runshi XuDepartment of Pathology, Medical School, Hunan University of Chinese Medicine, Changsha, China.
Yuxing ZhuDepartment of Oncology, Third Xiangya Hospital, Central South University, Changsha, China.
Dong HeDepartment of Respiration, The Second People's Hospital of Hunan Province of Hunan University of Chinese Medicine, Changsha, China.
YaXin ChengDepartment of Oncology, Third Xiangya Hospital, Central South University, Changsha, China.
Zhanwang WangDepartment of Oncology, Third Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0002-3655-0704
Xiang QingDepartment of Otolaryngology-Head and Neck Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
Ke CaoDepartment of Oncology, Third Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0001-5392-2306
Central South University · CNHunan University of Traditional Chinese Medicine · CN

Funding

National Natural Science Foundation of China 81874137
6 · The paper itself

Abstract

objectiveHypoxia, which can considerably affect the tumor microenvironment, hinders the use of immunotherapy in bladder cancer (BLCA). Therefore, we aimed to identify reliable hypoxia-related biomarkers to guide clinical immunotherapy in BLCA.

methodsUsing data downloaded from TCGA-BLCA cohort, we determined BLCA subtypes which divide 408 samples into different subtypes. Tumor immune infiltration levels of two clusters were quantified using ssGSEA, MCPcounter, EPIC, ESTIMATE, and TIMER algorithms. Next, we constructed a hypoxia score based on the expression of hypoxia-related genes. The IMvigor210 cohort and SubMap analysis were used to predict immunotherapeutic responses in patients with different hypoxia scores. Hub genes were screened using cytoscape, immunohistochemistry (IHC), and multispectral immunofluorescence were used to detect the spatial distribution of immune markers.

resultsPatients with BLCA were categorized into cluster1 (n = 227) and Cluster2 (n = 181). Immune infiltration and expression of immune markers were higher in Cluster1. Immune infiltration was also more obvious in the high-hypoxia score group which related to a better predicted response to immunotherapy. IHC, and multispectral immunofluorescence confirmed the importance of TLR8 in immune infiltration and immune phenotype.

conclusionsBLCA subtype can evaluate the infiltration of immune cells in the tumor microenvironment of different patients. Hypoxia score in this study could effectively predict immunotherapeutic responses in patients with BLCA. TLR8 may be a potential target for clinical immunotherapy.

Indexed as

Toll-Like Receptor 8Urinary Bladder NeoplasmsBiomarkersHumansHypoxiaImmunotherapyTumor MicroenvironmentBiomarkersToll-Like Receptor 8bladder cancerhypoxiaimmune checkpoint inhibitorTLR8tumor microenvironment

Identifiers

PMID38063246
PMCPMC10757107
OpenAlexW4389489789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.