Evidence map›Paper›PMID 38063008›Full record

ArticleAIDS research and human retroviruses2024

Virologic Nonsuppression and HIV Drug Resistance Among People Who Inject Drugs and Their Sexual and Injecting Partners in Kenya.

Bhavna H Chohan, Hanley Kingston, Ashley S Tseng, Betsy Sambai, Brandon L Guthrie, Eduan Wilkinson, Jennifer Giandhari, Loice W Mbogo, Aliza Monroe-Wise, Sarah Masyuko and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

Bhavna H ChohanDepartment of Global Health, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-2125-6799
Hanley KingstonInstitute of Public Health Genetics, University of Washington, Seattle, Washington, USA.
Ashley S TsengDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-2304-579X
Betsy SambaiUniversity of Washington Global Assistance Program-Kenya, Nairobi, Kenya.
Brandon L GuthrieDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Eduan WilkinsonKwaZulu-Natal Research Innovation and Sequencing Platform, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Jennifer GiandhariKwaZulu-Natal Research Innovation and Sequencing Platform, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Loice W MbogoUniversity of Washington Global Assistance Program-Kenya, Nairobi, Kenya.
Aliza Monroe-WiseDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Sarah MasyukoDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Rose BosireKenya Medical Research Institute, Nairobi, Kenya.
Natasha T Ludwig-BarronDepartment of Global Health, University of Washington, Seattle, Washington, USA.
William SinkeleSupport for Addictions Prevention and Treatment in Africa (SAPTA), Nairobi, Kenya.
David BukusiKenyatta National Hospital, Nairobi, Kenya.
Tulio de OliveriaDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Carey FarquharDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Joshua T HerbeckDepartment of Global Health, University of Washington, Seattle, Washington, USA.
University of Washington · USUnited States International University Africa · KEKenya Medical Research Institute · KEKenyatta National Hospital · KEPartners for Health and Development in Africa · KEStellenbosch University · ZAUniversity of KwaZulu-Natal · ZA

Funding

TRAINEESHIPS IN AIDS PREVENTION STUDIEST32MH019105 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carol Suzanne Camlin, Glenn-Milo Santos · 1989 to 2026
$15.3M
Integrating Assisted Partner Services and Phylogenetics for HIV and HCV PreventionR01DA043409 · NIDA · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY, HERBECK, JOSHUA T · 2017 to 2021
$3.6M
NIDA NIH HHS R01 DA043409NIMH NIH HHS T32 MH019105
6 · The paper itself

Abstract

We evaluated the prevalence and correlates of HIV viral nonsuppression and HIV drug resistance (HIV-DR) in a cohort of people who inject drugs living with HIV (PWID-LH) and their sexual and injecting partners living with HIV in Kenya. HIV-DR testing was performed on participants with viral nonsuppression. Of 859 PWID-LH and their partners, 623 (72.5%) were on antiretroviral therapy (ART) ≥4 months and 148/623 (23.8%) were not virally suppressed. Viral nonsuppression was more common among younger participants and those on ART for a shorter duration. Among 122/148 (82.4%) successfully sequenced samples, 55 (45.1%) had detectable major HIV-DR mutations, mainly to non-nucleoside and nucleotide reverse transcriptase inhibitors (NNRTI and NRTI). High levels of HIV-DR among those with viral nonsuppression suggests need for viral load monitoring, adherence counseling, and timely switching to alternate ART regimens in this key population.

Indexed as

Drug Resistance, ViralHIV InfectionsSexual PartnersSubstance Abuse, IntravenousAdultAnti-HIV AgentsCohort StudiesFemaleHIV-1HumansKenyaMaleMiddle AgedPrevalenceViral LoadYoung AdultAnti-HIV AgentsHIVHIV drug resistanceKenyaPWIDvirologic nonsuppression

Identifiers

PMID38063008
PMCPMC11295789
OpenAlexW4389487133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.