Evidence map›Paper›PMID 38062879›Full record

SynthesisJournal of cachexia, sarcopenia and muscle2024

Skeletal muscle atrophy in clinical and preclinical models of chronic kidney disease: A systematic review and meta-analysis.

Ashley D Troutman, Eliott Arroyo, Elizabeth M Sheridan, Duncan J D'Amico, Peyton R Brandt, Rachel Hinrichs, Xiwei Chen, Kenneth Lim, Keith G Avin

Open access · goldAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ashley D TroutmanDepartment of Physical Therapy, School of Health and Human Sciences, Indiana University Purdue University, Indianapolis, Indiana, USA.
Eliott ArroyoDepartment of Medicine, Division of Nephrology & Hypertension, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Elizabeth M SheridanDepartment of Physical Therapy, School of Health and Human Sciences, Indiana University Purdue University, Indianapolis, Indiana, USA.
Duncan J D'AmicoDepartment of Physical Therapy, School of Health and Human Sciences, Indiana University Purdue University, Indianapolis, Indiana, USA.
Peyton R BrandtDepartment of Physical Therapy, School of Health and Human Sciences, Indiana University Purdue University, Indianapolis, Indiana, USA.
Rachel HinrichsUniversity Library, Indiana University-Purdue University Indianapolis, Indiana, USA.
Xiwei ChenDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University Bloomington, Bloomington, Indiana, USA.
Kenneth LimDepartment of Medicine, Division of Nephrology & Hypertension, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Keith G AvinDepartment of Physical Therapy, School of Health and Human Sciences, Indiana University Purdue University, Indianapolis, Indiana, USA.ORCID 0000-0001-9426-7862
University of Indianapolis · USHypertension Institute · USIndiana University Bloomington · US

Funding

Redefining cardiovascular risk assessment in dialysis patients (ROCK-D) studyR01HL166747 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Kenneth Lim · 2023 to 2026
$3.0M
Dissecting the role of soluble α-Klotho in cardiovascular agingK23DK115683 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LIM, KENNETH · 2018 to 2022
$912k
Mechanisms of Interventions to Ameliorate Sarcopenia in Chronic Kidney DiseaseK08DK110429 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI AVIN, KEITH G · 2016 to 2021
$718k
Enhancing Fatty Acid Oxidation Will Improve Skeletal Muscle & Enable Exercise Adaptation in CKDR03DK125665 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI AVIN, KEITH G · 2020 to 2021
$238k
NHLBI NIH HHS R01 HL166747NIDDK NIH HHS K08 DK110429NIDDK NIH HHS K23 DK115683NIDDK NIH HHS R03 DK125665
6 · The paper itself

Abstract

Patients with chronic kidney disease (CKD) are often regarded as experiencing wasting of muscle mass and declining muscle strength and function, collectively termed sarcopenia. The extent of skeletal muscle wasting in clinical and preclinical CKD populations is unclear. We evaluated skeletal muscle atrophy in preclinical and clinical models of CKD, with multiple sub-analyses for muscle mass assessment methods, CKD severity, sex and across the different preclinical models of CKD. We performed a systematic literature review of clinical and preclinical studies that measured muscle mass/size using the following databases: Ovid Medline, Embase and Scopus. A random effects meta-analysis was utilized to determine standard mean difference (SMD; Hedges' g) between healthy and CKD. Heterogeneity was evaluated using the I

Indexed as

Diabetes MellitusRenal Insufficiency, ChronicFemaleHumansMaleMuscle, SkeletalMuscular AtrophyRenal DialysisAtrophyChronic kidney disease, sex-differences, dialysisSarcopeniaSkeletal muscle

Identifiers

PMID38062879
PMCPMC10834351
OpenAlexW4389485989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.