Evidence map›Paper›PMID 38062633›Full record

Observational studyEpilepsia2024

A multi-center comparison of surgical techniques for corpus Callosotomy in pediatric drug-resistant epilepsy.

Daniel Hansen, Sabrina Shandley, Joffre Olaya, Jason Hauptman, Kurtis Auguste, Adam P Ostendorf, Dewi F Depositario-Cabacar, Lily C Wong-Kisiel, Shilpa B Reddy, Michael J McCormack and 25 more

Open access · bronzeAbstract readObservational StudyMulticenter Study
PubMed Publisher
In one paragraph

Observational study in Epilepsia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Treatment of pediatric epilepsy.Pediatric investigation · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Head-to-Head comparison of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 1 country.

Daniel HansenJane and John Justin Institute for Mind Health, Cook Children's Medical Center, Fort Worth, Texas, USA.ORCID https://orcid.org/0009-0003-3663-4048
Sabrina ShandleyJane and John Justin Institute for Mind Health, Cook Children's Medical Center, Fort Worth, Texas, USA.
Joffre OlayaChildren's Hospital of Orange County, Orange, California, USA.
Jason HauptmanDivision of Pediatric Neurosurgery, University of Washington/Seattle Children's Hospital, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-2035-9876
Kurtis AugusteUniversity of California San Francisco Weill Institute for Neurosciences, Benioff Children's Hospital, San Francisco, California, USA.
Adam P OstendorfDepartment of Pediatrics, Nationwide Children's Hospital, Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-9994-6650
Dewi F Depositario-CabacarCenter for Neuroscience, Children's National Hospital, George Washington University School of Medicine, Washington, District of Columbia, USA.
Lily C Wong-KisielDepartment of Neurology, Divisions of Child Neurology and Epilepsy, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Shilpa B ReddyDepartment of Pediatric Neurology, Vanderbilt University, Monroe Carell Jr Children's Hospital, Nashville, Tennessee, USA.
Michael J McCormackDepartment of Pediatric Neurology, Vanderbilt University, Monroe Carell Jr Children's Hospital, Nashville, Tennessee, USA.
Ernesto Gonzalez-GiraldoUniversity of California San Francisco Weill Institute for Neurosciences, Benioff Children's Hospital, San Francisco, California, USA.
Joseph SullivanUniversity of California San Francisco Weill Institute for Neurosciences, Benioff Children's Hospital, San Francisco, California, USA.
Javarayee PradeepDepartment of Pediatric Neurology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Rani K SinghDivision of Neurology, Department of Pediatrics, Atrium Health/Levine Children's Hospital, Charlotte, North Carolina, USA.
Erin Fedak RomanowskiDepartment of Pediatrics, Division of Pediatric Neurology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Nancy A McNamaraDepartment of Pediatrics, Division of Pediatric Neurology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Michael A CilibertoDepartment of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Priya TatacharDepartment of Pediatrics, Ann and Robert H Lurie Children's Hospital, Chicago, Illinois, USA.
Daniel W ShreyChildren's Hospital of Orange County, Orange, California, USA.
Cemal KarakasDepartment of Neurology, Norton Children's Hospital, University of Louisville School of Medicine, Louisville, Kentucky, USA.ORCID https://orcid.org/0000-0002-9516-2285
Samir KariaDepartment of Neurology, Norton Children's Hospital, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Ammar KhederDepartment of Pediatrics, Emory University College of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Satyanarayana GedelaDepartment of Pediatrics, Emory University College of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Allyson AlexanderDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Krista EschbachDepartment of Neurology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0002-4249-338X
Jeffrey BoltonDepartment of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA.
Ahmad MarashlyDepartment of Neurology, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Steven WolfBoston Children's Health Physicians of New York and Connecticut, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York, USA.ORCID https://orcid.org/0000-0002-7602-3474
Patricia McGoldrickBoston Children's Health Physicians of New York and Connecticut, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York, USA.
Srishti NangiaWeill-Cornell Medicine, New York City, New York, USA.
Zachary GrinspanWeill-Cornell Medicine, New York City, New York, USA.ORCID https://orcid.org/0000-0001-6705-0932
Jason CoryellDoernbecher Children's Hospital, Oregon Health and Sciences University, Oregon Health Science Center, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-1442-5259
Debopam SamantaDepartment of Neurology, Arkansas Children's Hospital, Little Rock, Arkansas, USA.ORCID https://orcid.org/0000-0002-5154-8717
Dallas ArmstrongDepartment of Neurology, University of Texas Southwestern, Dallas, Texas, USA.
M Scott PerryJane and John Justin Institute for Mind Health, Cook Children's Medical Center, Fort Worth, Texas, USA.ORCID https://orcid.org/0000-0002-1825-846X
Cook Children's Medical Center · USUniversity of California, San Francisco · USChildren's Hospital Colorado · USChildren's Hospital of Orange County · USCornell University · USEmory University · USMichigan Medicine · USMonroe Carell Jr. Children's Hospital · USNew York Medical College · USUniversity of Louisville · USArkansas Children's Hospital · USBoston Children's Hospital · USChildren's Hospital of Wisconsin · USDoernbecher Children's Hospital · USGeorge Washington University Hospital · USJohns Hopkins Hospital · USLevine Children's Hospital · USLurie Children's Hospital · USMayo Clinic · USNationwide Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCorpus callosotomy (CC) is used to reduce seizures, primarily in patients with generalized drug-resistant epilepsy (DRE). The invasive nature of the procedure contributes to underutilization despite its potential superiority to other palliative procedures. The goal of this study was to use a multi-institutional epilepsy surgery database to characterize the use of CC across participating centers.

methodsData were acquired from the Pediatric Epilepsy Research Consortium (PERC) Surgery Database, a prospective observational study collecting data on children 0-18 years referred for surgical evaluation of DRE across 22 U.S. pediatric epilepsy centers. Patient, epilepsy, and surgical characteristics were collected across multiple CC modalities. Outcomes and complications were recorded and analyzed statistically.

resultsEighty-three patients undergoing 85 CC procedures at 14 participating epilepsy centers met inclusion criteria. Mean age at seizure onset was 2.3 years (0-9.4); mean age for Phase I evaluation and surgical intervention were 9.45 (.1-20) and 10.46 (.2-20.6) years, respectively. Generalized seizure types were the most common (59%). Complete CC was performed in 88%. The majority of CC procedures (57%) were via open craniotomy, followed by laser interstitial thermal therapy (LiTT) (20%) and mini-craniotomy/endoscopic (mc/e) (22%). Mean operative times were significantly longer for LiTT, whereas mean estimated blood loss was greater in open cases. Complications occurred in 11 cases (13%) and differed significantly between surgical techniques (p < .001). There was no statistically significant difference in length of postoperative stay across approaches. Mean follow-up was 12.8 months (range 1-39). Favorable Engel outcomes were experienced by 37 (78.7%) of the patients who underwent craniotomy, 10 (58.8%) with LiTT, and 12 (63.2%) with mc/e; these differences were not statistically significant. SIGNIFICANCE: CC is an effective surgical modality for children with DRE. Regardless of surgical modality, complication rates are acceptable and seizure outcomes generally favorable. Newer, less-invasive, surgical approaches may lead to increased adoption of this efficacious therapeutic option for pediatric DRE.

Indexed as

Drug Resistant EpilepsyEpilepsyLaser TherapyPsychosurgeryChildChild, PreschoolCorpus CallosumHumansRetrospective StudiesSeizuresTreatment OutcomeLiTTminimally invasiveoutcomesseizuresurgery

Identifiers

PMID38062633
OpenAlexW4389485271

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.