Novel analytical method based on chemometric models applied to UV-Vis spectrophotometric data for simultaneous determination of Etoricoxib and Paracetamol in presence of Paracetamol impurities.

Mona A Abdel Rahman, Mohamed R Elghobashy, Hala E Zaazaa, Sally S El-Mosallamy

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Article in BMC chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

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9citing papers in PubMed

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9 citing papers in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Mona A Abdel RahmanAnalytical Chemistry Department, Faculty of Pharmacy, October 6 University, 6 October City, PO box 12858, Giza, Egypt.

Mohamed R ElghobashyAnalytical Chemistry Department, Faculty of Pharmacy, October 6 University, 6 October City, PO box 12858, Giza, Egypt.

Hala E ZaazaaAnalytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St, PO 11562, Cairo, Egypt.

Sally S El-MosallamyAnalytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St, PO 11562, Cairo, Egypt. sally.el-mosallamy@pharma.cu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The multivariate models that are used for spectral data analysis have many beneficial applications, and one of the important applications is the analysis of drugs and their impurities. Three Chemometrically-assisted spectrophotometric models have been proposed and validated. The proposed models are Partial Least Squares (PLS), Artificial Neural Networks (ANN), and Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS). The advanced chemometric models were applied to resolve the significantly overlapping spectra of Etoricoxib (ETO) and Paracetamol (PCM), along with impurities of PCM namely; P-aminophenol (PAP) and P-hydroxy acetophenone (PHA). The proposed models succeeded in simultaneously analyzing the mixture of ETO and PCM along with the impurities of PCM. So, the proposed techniques can be used without requiring a separation step in the analysis of pharmaceutical formulation. Moreover, no significant differences were found when the results of the suggested and published chemometric models were compared statistically with the reported HPLC method.

Indexed as

ANNEtoricoxibImpuritiesMCR-ALSParacetamolPLS

Identifiers

PMID38062520

DOI10.1186/s13065-023-01095-x

PMCPMC10702036

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