ArticleEnvironmental health : a global access science source2023
Association of air pollution exposure and increased coronary artery disease risk: the modifying effect of genetic susceptibility.
Article in Environmental health : a global access science source, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Gene-Air Pollution Interaction in Cardiovascular Disease: Lights and Shadows in a Tangled Risk Factor Network.International journal of molecular sciences · 2026Review
- Targeting bromodomain and extraterminal proteins in cardiovascular disease: Pathological mechanisms and therapeutic applications.The Journal of international medical research · 2026Review
- Synergistic effects of genetic susceptibility and air pollution on cardiovascular disease.American journal of preventive cardiology · 2026Article
- Modifiable influencing factors and their joint effects on early- and late-onset coronary heart disease.Nature communications · 2025Article
- Effects of PM2.5 Metal Components Derived From Porcine Farm Exposure on Sperm Function in Mice.Journal of biochemical and molecular toxicology · 2025Article
- Neutrophil percentage-to-albumin ratio and the risk of all-cause and cardiovascular mortality: a 20-year follow-up cohort study of 36,428 US adults.BMC public health · 2025Article
- Exploring genetic susceptibility to air pollution and its implications for disease risk and precision health: A scoping review.AIMS public health · 2025Review
- Air pollution and coronary atherosclerosis.Future cardiology · 2025Review
- Climate Change and Health: A Study of the Attitudes of Future Science Teachers.International journal of environmental research and public health · 2024Article
- Distinct methylome profile of cfDNA in AMI patients reveals significant alteration in cAMP signaling pathway genes regulating cardiac muscle contraction.Clinical epigenetics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundBoth genetic factors and air pollution are risk factors for coronary artery disease (CAD), but their combined effects on CAD are uncertain. The study aimed to comprehensively investigate their separate, combined and interaction effects on the onset of CAD.
methodsWe utilized data from the UK Biobank with a recruitment of 487,507 participants who were free of CAD at baseline from 2006 to 2010. We explored the separate, combined effect or interaction association among genetic factors, air pollution and CAD with the polygenic risk score (PRS) and Cox proportional hazard models.
resultsThe hazard ratios (HRs) [95% confidence interval (CI)] of CAD for 10-µg/m
conclusionExposure to air pollution was significantly related to an increased CAD risk, which could be further strengthened by CAD gene susceptibility. Additionally, there were positive additive interactions between genetic factors and air pollution on the onset of CAD. This can provide a more comprehensive, precise and individualized scientific basis for the risk assessment, prevention and control of CAD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.