Evidence map›Paper›PMID 38062305›Full record

ArticleCurrent microbiology2023

Antimicrobial and Cytotoxic Secondary Metabolites from a Marine-Derived Fungus Penicillium Citrinum VM6.

Nguyen Mai Anh, Vu Thi Thu Huyen, Vu Thi Quyen, Phi Thi Dao, Do Thi Quynh, Doan Thi Mai Huong, Pham Van Cuong, Ton That Huu Dat, Le Thi Hong Minh

Abstract read
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In one paragraph

Article in Current microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Novel Antifungal Pyridine Alkaloids from Endophytic FungusJournal of fungi (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Article
  6. Bio-guided discovery of antibacterial metabolites fromJournal of enzyme inhibition and medicinal chemistry · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nguyen Mai AnhInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.ORCID https://orcid.org/0009-0002-8412-7182
Vu Thi Thu HuyenInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.ORCID https://orcid.org/0000-0002-3211-5254
Vu Thi QuyenInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.ORCID https://orcid.org/0009-0000-3606-2375
Phi Thi DaoInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.ORCID https://orcid.org/0009-0001-8043-978X
Do Thi QuynhInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.ORCID https://orcid.org/0009-0004-1539-5460
Doan Thi Mai HuongInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.ORCID https://orcid.org/0000-0003-3252-870X
Pham Van CuongInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.ORCID https://orcid.org/0000-0003-1317-6382
Ton That Huu DatMientrung Institute for Scientific Research, Vietnam National Museum of Nature, VAST, 321 Huynh Thuc Khang, Thua Thien Hue, Vietnam. tthdat@vnmn.vast.vn.ORCID https://orcid.org/0000-0002-6500-3363
Le Thi Hong MinhInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. lhminh@imbc.vast.vn.ORCID https://orcid.org/0000-0002-1710-942X

Funding

Vietnam Academy of Science and Technology VAST06.03/22-23
6 · The paper itself

Abstract

Investigation of an antimicrobial and cytotoxic ethyl acetate extract prepared from solid fermentation of the marine-derived fungus Penicillium citrinum VM6 led to the isolation of eight metabolites (1-8), including one citrinin dimer dicitrinone F (1). Of these, compound 7 was isolated for the first time from the Penicillium genus and compound 1 with carbon-bridged C-7/C-7' linkage is rarely reported. All compounds (1-8) exhibited selective antimicrobial activity against the tested Gram-positive bacteria and Candida albicans with MICs of 32-256 µg/mL. Compounds 1 and 8 exhibited cytotoxicity against all tested cell lines A549, MCF7, MDA-MB-231, Hela, and AGS with IC

Indexed as

Anti-Infective AgentsAntineoplastic AgentsPenicilliumFungiMolecular StructureAnti-Infective AgentsAntineoplastic AgentsCinitrin dimerCytotoxicPenicillium citrinumSteroid, Antibacterial

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.