Evidence map›Paper›PMID 38062304›Full record

ArticleNeurocritical care2024

Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group in the Pediatric Population.

Varina L Boerwinkle, Brian Appavu, Emilio Garzon Cediel, Jennifer Erklaurer, Saptharishi Lalgudi Ganesan, Christie Gibbons, Cecil Hahn, Kerri L LaRovere, Dick Moberg, Girija Natarajan and 4 more

Erratum issuedAbstract read
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In one paragraph

Article in Neurocritical care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 13 institutions in 3 countries.

Varina L BoerwinkleDepartment of Neurology, University of North Carolina in Chapel Hill, Chapel Hill, NC, USA. Varina_Boerwinke@med.unc.edu.ORCID 0000-0002-1429-2994
Brian AppavuDepartment of Child Health and Neurology, University of Arizona College of Medicine - Phoenix, Phoenix, AZ, USA.
Emilio Garzon CedielDepartment of Neurology, University of North Carolina in Chapel Hill, Chapel Hill, NC, USA.
Jennifer ErklaurerDivisions of Critical Care Medicine and Child Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Saptharishi Lalgudi GanesanDepartments of Paediatrics and Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Christie GibbonsBrain Injury Association of America Family Advocate, Phoenix, AZ, USA.
Cecil HahnDepartment of Paediatrics (Neurology), The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Kerri L LaRovereDepartment of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Dick MobergMoberg Analytics, Inc., Philadelphia, PA, USA.
Girija NatarajanDiscipline of Pediatrics, Children's Hospital of Michigan and Hutzel Women's Hospital, Central Michigan University, Mount Pleasant, MI, USA.
Erika MolteniSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
William R ReutherDepartment of Neurology, University of North Carolina in Chapel Hill, Chapel Hill, NC, USA.
Beth S SlomineDepartment of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD, USA.
Curing Coma Campaign, its Contributing Members
University of North Carolina at Chapel Hill · USCentral Michigan University · USUniversity of Arizona · USWestern University · CABrain Injury Association of America · USUniversity of Toronto · CABaylor College of Medicine · USBoston Children's Hospital · USKennedy Krieger Institute · USKing's College London · GBJohns Hopkins University · USMoberg Research (United States) · USUniversity of Phoenix · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe fundamental gap obstructing forward progress of evidenced-based care in pediatric and neonatal disorders of consciousness (DoC) is the lack of defining consensus-based terminology to perform comparative research. This lack of shared nomenclature in pediatric DoC stems from the inherently recursive dilemma of the inability to reliably measure consciousness in the very young. However, recent advancements in validated clinical examinations and technologically sophisticated biomarkers of brain activity linked to future abilities are unlocking this previously formidable challenge to understanding the DoC in the developing brain.

methodsTo address this need, the first of its kind international convergence of an interdisciplinary team of pediatric DoC experts was organized by the Neurocritical Care Society's Curing Coma Campaign. The multidisciplinary panel of pediatric DoC experts proposed pediatric-tailored common data elements (CDEs) covering each of the CDE working groups including behavioral phenotyping, biospecimens, electrophysiology, family and goals of care, neuroimaging, outcome and endpoints, physiology and big Data, therapies, and pediatrics.

resultsWe report the working groups' pediatric-focused DoC CDE recommendations and disseminate CDEs to be used in studies of pediatric patients with DoC.

conclusionsThe CDEs recommended support the vision of progressing collaborative and successful internationally collaborative pediatric coma research.

Indexed as

Biomedical ResearchCommon Data ElementsChildComaConsciousnessConsciousness DisordersHumansInfant, NewbornComaCommon data elementsConsciousnessDisorder of consciousnessNeonatalPediatricStandardization

Identifiers

PMID38062304
OpenAlexW4389428149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.