SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2024
Kyphoplasty is associated with reduced mortality risk for osteoporotic vertebral compression fractures: a systematic review and meta-analysis.
Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 8 citations in OpenAlex.
- Comparison of near- and midterm outcomes of two unilateral percutaneous translaminar vertebral kyphoplasty procedures for the treatment of single-segment OVCF: a single-center randomized controlled study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Trial
- Prognostic value of serum estradiol and sclerostin for predicting fracture healing in postmenopausal women with osteoporotic vertebral compression fractures.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Association Between Adjacent Disc Vacuum Phenomenon and Adjacent Vertebral Fracture After Balloon Kyphoplasty for Osteoporotic Vertebral Fractures: A Retrospective Multicenter Study.Global spine journal · 2026Article
- Predicting long-term clinical mortality of elderly patients with vertebral compression fractures.Frontiers in medicine · 2026Article
- Development and validation of a predictive model for postoperative residual low back pain following percutaneous kyphoplasty or percutaneous vertebroplasty.American journal of translational research · 2026Article
- Genant grade-based stratification in percutaneous curved kyphoplasty: Superior early analgesic efficacy and cement distribution characteristics in moderate to severe osteoporotic vertebral compression fractures.Neurosurgical review · 2025Article
- Incidence of New Fractures in Patients Treated with Kyphoplasty/Vertebroplasty or Conservative Methods.Medicina (Kaunas, Lithuania) · 2025Article
- Unilateral Percutaneous Curved Kyphoplasty versus Bilateral Percutaneous Kyphoplasty for the Treatment of Single-Level Osteoporotic Vertebral Compression Fractures: A Retrospective Comparative Study.Journal of pain research · 2025Article
- Percutaneous kyphoplasty improves surgical outcomes and quality of life in elderly patients with osteoporotic vertebral compression fractures.American journal of translational research · 2025Article
- Safety and efficacy of robot-assisted percutaneous kyphoplasty under local anesthesia in a day-surgery setting for osteoporotic vertebral compression fractures.Frontiers in surgery · 2025Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundVertebral augmentation, such as vertebroplasty (VP) or kyphoplasty (KP), has been utilized for decades to treat OVCFs; however, the precise impact of this procedure on reducing mortality risk remains a topic of controversy. This study aimed to explore the potential protective effects of vertebral augmentation on mortality in patients with osteoporotic vertebral compression fractures (OVCFs) using a large-scale meta-analysis. MATERIALS AND
methodsCochrane Library, Embase, MEDLINE, PubMed and Web of Science databases were employed for literature exploration until May 2023. The hazard ratios (HRs) and 95% confidence intervals (CIs) were utilized as a summary statistic via random-effect models. Statistical analysis was executed using Review Manager 5.3 software.
resultsAfter rigorous screening, a total of five studies with substantial sample sizes were included in the quantitative meta-analysis. The total number of participants included in the study was an 2,421,178, comprising of 42,934 cases of vertebral augmentation and 1,991,244 instances of non-operative management. The surgical intervention was found to be significantly associated with an 18% reduction in the risk of mortality (HR 0.82; 95% CI 0.78, 0.85). Subgroup analysis revealed a remarkable 71% reduction in mortality risk following surgical intervention during short-term follow-up (HR 0.29; 95% CI 0.26, 0.32). Furthermore, KP exhibited a superior and more credible decrease in the risk of mortality when compared to VP treatment.
conclusionsBased on a comprehensive analysis of large samples, vertebral augmentation has been shown to significantly reduce the mortality risk associated with OVCFs, particularly in the early stages following fractures. Furthermore, it has been demonstrated that KP is more reliable and effective than VP in terms of mitigating mortality risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.