SynthesisNature medicine2023
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 6 pooled it
51.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
134 citing papers in PubMed, 6 syntheses or guidelines pooled it, 166 citations in OpenAlex.
- Does illicit drug use increase stroke risk? A systematic review, meta-analyses, and Mendelian randomization analysis.International journal of stroke : official journal of the International Stroke Society · 2026Pooled it
- Genome-wide meta-analyses of cross substance use disorders in diverse populations.Molecular psychiatry · 2026Pooled it
- Multi-ancestry investigation of the genomics of erectile dysfunction.Nature communications · 2025Pooled it
- Multi-ancestry sequencing-based genome-wide association study of C-reactive protein in 513,273 genomes.Nature communications · 2025Pooled it
- Gene expression differences associated with alcohol use disorder in human brain.Molecular psychiatry · 2025Pooled it
- A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.Nature human behaviour · 2024Pooled it
- Moderation of treatment outcomes by polygenic risk for alcohol-related traits in placebo-controlled trials of topiramate.Alcohol, clinical & experimental research · 2025Trial
- Advancing models of PTSD-AUD comorbidity: protocol for a multimethod framework using genetics and ecological momentary assessment.European journal of psychotraumatology · 2026Article
- Exploring the Pleiotropic Genetic Architecture of Substance Use Disorders: Findings From Phenome-Wide Association Studies.Biological psychiatry global open science · 2026Review
- GLP-1 Receptor Agonist and GIP/GLP-1 Receptor Dual Agonist Therapeutics at the Intersection of Alcohol Use Disorder, Obesity, and Cardiometabolic Dysfunction.Biological psychiatry global open science · 2026Review
- High false sign rates in transcriptome-wide association studies.Nature genetics · 2026Article
- Multiancestry conditional and joint analysis applied to GWAS summary statistics.Nature genetics · 2026Article
- Multi-omic spatial mapping of the human habenula defines the molecular and anatomical organization of medial and lateral subregions.bioRxiv : the preprint server for biology · 2026Article
- Convex approaches to isolate the shared and distinct genetic components of complex traits.Bioinformatics (Oxford, England) · 2026Article
- Three dimensional reconstruction of the human nucleus accumbens reveals topographic organization and molecular heterogeneity of D1-islands across the anterior posterior axis.bioRxiv : the preprint server for biology · 2026Article
- Classification of Alcohol Use Disorder With Explainable AI.Alcohol, clinical & experimental research · 2026Article
- Assessing measurement bias in substance use disorder criteria associated with childhood adversity and genetic liability.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- The genetics of fibromyalgia and its relationships to psychiatric and medical traits.Nature communications · 2026Article
- Shared genetic architecture and neurobiological pathways of problematic alcohol use and anxiety disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Polygenic scores in psychiatric research and clinical practice.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
49 authors at 20 institutions in 3 countries.
Hang Zhou *Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA. hang.zhou@yale.edu.ORCID 0000-0002-7694-6391
Rachel L Kember *Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.ORCID 0000-0001-8820-2659
Joseph D DeakDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0540-6080
Heng XuDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sylvanus ToikumoCrescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Kai YuanStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Penelope A LindPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Leila FarajzadehDepartment of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.
Lu WangDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Alexander S HatoumDepartment of Psychological and Brain Sciences, Washington University in St. Louis, Saint Louis, MO, USA.
Jessica JohnsonPamela Sklar Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hyunjoon LeePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Travis T MallardStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-3265-3001
Jiayi XuDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6379-386X
Keira J A JohnstonDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1370-3149
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0003-0394-777X
Trine Tollerup NielsenDepartment of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.
Marco GalimbertiDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6052-156X
Cecilia DaoDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Daniel F LeveyDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8431-9569
Cassie OverstreetDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Enda M ByrneChild Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
Nathan A GillespieInstitute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Scott GordonGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0001-7623-328X
Ian B HickieBrain and Mind Centre, University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0001-8832-9895
John B WhitfieldGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0002-1103-0876
Ke XuDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6472-7052
Hongyu ZhaoDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0003-1195-9607
Laura M HuckinsDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-5369-6502
Lea K DavisVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Sandra Sanchez-RoigeDepartment of Medicine, Division of Medical Genetics, Vanderbilt University Medical Center, Nashville, TN, USA.
Pamela A F MaddenDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-4069-8020
Tian GeStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jordan W SmollerStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
David M HougaardThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.ORCID 0000-0001-5928-3517
Anders D BørglumDepartment of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-8627-7219
Ditte DemontisDepartment of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-9124-2766
John H KrystalDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6952-1726
J Michael GazianoMassachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Boston Veterans Affairs Healthcare System, Boston, MA, USA.
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-0344-9690
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-0313-793X
Million Veteran Program
Amy C JusticeVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.ORCID 0000-0003-0139-5502
Murray B SteinDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-9564-2871
Henry R KranzlerCrescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.ORCID 0000-0002-1018-0450
Joel GelernterDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA. joel.gelernter@yale.edu.ORCID 0000-0002-4067-1859
Yale University · USBroad Institute · USWashington University in St. Louis · USVeterans Health Administration · USAarhus University · DKQIMR Berghofer Medical Research Institute · AUThe University of Queensland · AUBrigham and Women's Hospital · USIcahn School of Medicine at Mount Sinai · USIndiana University School of MedicineMassachusetts General Hospital · USQueensland University of Technology · AUStatens Serum Institut · DKThe University of Sydney · AUUnited States Department of Veterans Affairs · USUniversity of California San Diego · USUniversity of Pennsylvania · USVanderbilt University Medical Center · USVirginia Commonwealth University · USYale Cancer Center · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MPhenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MTranslational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI John H. Krystal · 2001 to 2026
$43.7MYale-SCORE Resource Support CoreU54AA027989 · NIAAA · YALE UNIVERSITY · PI Sherry Ann McKee · 2020 to 2026
$13.0MPILOT--GENETIC EPIDEMIOLOGY OF ALCOHOL AND TOBACCO CONSUMPTION IN CHINESE SAMPLEP50AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI SHER, KENNETH JAMES · 1999 to 2008
$12.6MTHE GENETICS OF VULNERABILITY TO NICOTINE ADDICTIONSR01DA012854 · NIDA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN · 2000 to 2013
$10.4M2/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124851 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOERGLUM, ANDERS, DAVIS, LEA K · 2021 to 2025
$5.4MMolecular Epidemiology of Alcoholism 3 - EDAC FamiliesR01AA013321 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2001 to 2005
$4.3M7/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01DA054869 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2021 to 2025
$3.3MMolecular Epidemiology of Alcoholism 2- Big SibshipsR01AA013320 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2003 to 2007
$3.1M5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9MBuilding Bridges to Allow Cross-species Translational genetics for the Study of AddictionDP1DA054394 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANCHEZ ROIGE, SANDRA · 2021 to 2025
$2.4MBLRD VA I01 BX003341BLRD VA I01 BX004820CSRD VA I01 CX001849NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR001878NCI NIH HHS R21 CA252916NHGRI NIH HHS R01 HG012354NIAAA NIH HHS K01 AA028292NIAAA NIH HHS K01 AA030083NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P50 AA011998NIAAA NIH HHS P50 AA012870NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA007728NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA014041NIAAA NIH HHS R01 AA026364NIAAA NIH HHS R37 AA007728NIAAA NIH HHS T32 AA028259NIAAA NIH HHS U54 AA027989NIDA NIH HHS DP1 DA054394NIDA NIH HHS K01 DA051759NIDA NIH HHS K08 DA019951NIDA NIH HHS R00 DA023549NIDA NIH HHS R01 DA012854NIDA NIH HHS R01 DA054869NIDA NIH HHS R56 DA012854NIH HHS S10 OD018522NIH HHS S10 OD026880NIMH NIH HHS R01 MH124839NIMH NIH HHS R01 MH124851NIMH NIH HHS U01 MH109514
Abstract
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N = 903,147; African, N = 122,571; Latin American, N = 38,962; East Asian, N = 13,551; and South Asian, N = 1,716 ancestries). We observed a high degree of cross-ancestral similarity in the genetic architecture of PAU and identified 110 independent risk variants in within- and cross-ancestry analyses. Cross-ancestry fine mapping improved the identification of likely causal variants. Prioritizing genes through gene expression and chromatin interaction in brain tissues identified multiple genes associated with PAU. We identified existing medications for potential pharmacological studies by a computational drug repurposing analysis. Cross-ancestry polygenic risk scores showed better performance of association in independent samples than single-ancestry polygenic risk scores. Genetic correlations between PAU and other traits were observed in multiple ancestries, with other substance use traits having the highest correlations. This study advances our knowledge of the genetic etiology of PAU, and these findings may bring possible clinical applicability of genetics insights-together with neuroscience, biology and data science-closer.
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AlcoholismRacial GroupsGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPhenotypePolymorphism, Single Nucleotide
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