Evidence map›Paper›PMID 38062249›Full record

ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2024

Enzyme-free electrochemical biosensor based on bio-barcode amplification for ultra-sensitive detection of microRNA.

Huai Xi, Xiaolin Liang, Guidan Huang, Jinhua Liang, Dandan Li, Qilin Wen, Yun Zhang, Xiaofen Xiao, Wenyuan Zhu

Abstract read
PubMed Publisher
In one paragraph

Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Electrochemical analysis of miRNA for liquid biopsy.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huai XiCollege of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, 541004, China.
Xiaolin LiangCollege of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, 541004, China.
Guidan HuangCollege of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, 541004, China.
Jinhua LiangCollege of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, 541004, China.
Dandan LiCollege of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, 541004, China.
Qilin WenCollege of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, 541004, China.
Yun ZhangCollege of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, 541004, China.
Xiaofen XiaoKey Laboratory of Carbon Materials of Zhejiang Province, College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, Zhejiang, China. xiaoxf3@mail2.sysu.edu.cn.
Wenyuan ZhuCollege of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, 541004, China. wyzhu@glut.edu.cn.ORCID http://orcid.org/0000-0001-6862-3093

Funding

Central Government-Guided Local Science and Technology Development Project GuikeZY20198006
6 · The paper itself

Abstract

The rapid and accurate detection of miRNAs is of great significance for early diagnosis and treatment of cancer. Hence, a novel enzyme-free and label-free electrochemical biosensor based on bio-barcode amplification for detecting miRNAs was presented. Sandwich structures constructed of magnetic nanoparticles modified with DNA probes, gold nanoparticles with numerous barcoded DNA strands that hybridized with target miRNAs were fabricated as the amplifier. The released barcoded DNA strands then acted as the secondary targets and triggered the electrochemical sensor with a significant electrochemical response. A highly sensitive (detection limit of 0.24 fM) and selective electrochemical miRNA detection was realized, which has great potential for application in miRNA-related clinical diagnosis and biochemical research.

Indexed as

Biosensing TechniquesMetal NanoparticlesMicroRNAsDNAElectrochemical TechniquesGoldLimit of DetectionDNAGoldMicroRNAsBio-barcode amplificationElectrochemical biosensorEnzyme-freeMicroRNA

Identifiers

PMID38062249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.