Evidence map›Paper›PMID 38062139›Full record

ArticleScientific reports2023

The interplay between sex, time of day, fasting status, and their impact on cardiac mitochondrial structure, function, and dynamics.

Mariame S Kane, Gloria A Benavides, Edie Osuma, Michelle S Johnson, Helen E Collins, Yecheng He, David Westbrook, Silvio H Litovsky, Kasturi Mitra, John C Chatham and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
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  9. Research Progress of BMAL1 in Heart Failure.Journal of the American Heart Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 3 countries.

Mariame S KaneDepartment of Pathology, University of Alabama at Birmingham, 901 19th Street S., Birmingham, AL, BMRII-53435294-0017, USA.
Gloria A BenavidesDepartment of Pathology, University of Alabama at Birmingham, 901 19th Street S., Birmingham, AL, BMRII-53435294-0017, USA.
Edie OsumaDepartment of Pathology, University of Alabama at Birmingham, 901 19th Street S., Birmingham, AL, BMRII-53435294-0017, USA.
Michelle S JohnsonDepartment of Pathology, University of Alabama at Birmingham, 901 19th Street S., Birmingham, AL, BMRII-53435294-0017, USA.
Helen E CollinsDepartment of Pathology, University of Alabama at Birmingham, 901 19th Street S., Birmingham, AL, BMRII-53435294-0017, USA.
Yecheng HeDepartment of Pathology, University of Alabama at Birmingham, 901 19th Street S., Birmingham, AL, BMRII-53435294-0017, USA.
David WestbrookDepartment of Pathology, University of Alabama at Birmingham, 901 19th Street S., Birmingham, AL, BMRII-53435294-0017, USA.
Silvio H LitovskyDepartment of Pathology, University of Alabama at Birmingham, 901 19th Street S., Birmingham, AL, BMRII-53435294-0017, USA.
Kasturi MitraDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
John C ChathamDepartment of Pathology, University of Alabama at Birmingham, 901 19th Street S., Birmingham, AL, BMRII-53435294-0017, USA.
Victor Darley-UsmarDepartment of Pathology, University of Alabama at Birmingham, 901 19th Street S., Birmingham, AL, BMRII-53435294-0017, USA.
Martin E YoungDepartment of Medicine, University of Alabama at Birmingham, 703 19th St. S., ZRB 308, Birmingham, AL, 35294, USA. meyoung@uab.edu.
Jianhua ZhangDepartment of Pathology, University of Alabama at Birmingham, 901 19th Street S., Birmingham, AL, BMRII-53435294-0017, USA. jianhuazhang@uabmc.edu.
University of Alabama at Birmingham · USAshoka University · IN

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Sex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jianhua Zhang · 2015 to 2026
$11.3M
MECHANISMS OF HYPERTENSION AND CARDIOVASCULAR DISEASEST32HL007457 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Martin E Young · 1985 to 2026
$8.6M
Aberrant Circadian Regulation of Autophagy in the Heart During DiabetesR01HL142216 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHATHAM, JOHN C, YOUNG, MARTIN E · 2018 to 2021
$2.3M
Mechanisms Contributing to Pregnancy-induced Cardiac RemodelingR01HL163003 · NHLBI · UNIVERSITY OF LOUISVILLE · PI Helen E Collins · 2023 to 2026
$2.1M
DBT-Wellcome Trust India Alliance IA/S/20/2/505198NCI NIH HHS P30 CA013148NHLBI NIH HHS NHLBI HL142216NHLBI NIH HHS R01 HL142216NHLBI NIH HHS R01 HL163003NHLBI NIH HHS T32 HL007457NHLBI NIH HHS T32HL007457NIA NIH HHS AG050886NIA NIH HHS P30 AG050886
6 · The paper itself

Abstract

Mitochondria morphology and function, and their quality control by mitophagy, are essential for heart function. We investigated whether these are influenced by time of the day (TOD), sex, and fed or fasting status, using transmission electron microscopy (EM), mitochondrial electron transport chain (ETC) activity, and mito-QC reporter mice. We observed peak mitochondrial number at ZT8 in the fed state, which was dependent on the intrinsic cardiac circadian clock, as hearts from cardiomyocyte-specific BMAL1 knockout (CBK) mice exhibit different TOD responses. In contrast to mitochondrial number, mitochondrial ETC activities do not fluctuate across TOD, but decrease immediately and significantly in response to fasting. Concurrent with the loss of ETC activities, ETC proteins were decreased with fasting, simultaneous with significant increases of mitophagy, mitochondrial antioxidant protein SOD2, and the fission protein DRP1. Fasting-induced mitophagy was lost in CBK mice, indicating a direct role of BMAL1 in regulating mitophagy. This is the first of its kind report to demonstrate the interactions between sex, fasting, and TOD on cardiac mitochondrial structure, function and mitophagy. These studies provide a foundation for future investigations of mitochondrial functional perturbation in aging and heart diseases.

Indexed as

ARNTL Transcription FactorsMyocytes, CardiacAnimalsFastingMiceMice, KnockoutMitochondriaMitochondrial DynamicsARNTL Transcription Factors

Identifiers

PMID38062139
PMCPMC10703790
OpenAlexW4389426165

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.