Evidence map›Paper›PMID 38062033›Full record

ArticleNPJ Parkinson's disease2023

Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson's disease.

Gabriel Miltenberger-Miltenyi, Roberto A Ortega, Aloysius Domingo, Rachita Yadav, Ayumi Nishiyama, Deborah Raymond, Viktoriya Katsnelson, Nikita Urval, Matthew Swan, Vicki Shanker and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Multiple sclerosis inFrontiers in neurology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Gabriel Miltenberger-MiltenyiLaboratório de Genética, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. gmiltenyi@medicina.ulisboa.pt.ORCID http://orcid.org/0000-0003-0224-1281
Roberto A OrtegaDepartment of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Aloysius DomingoDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Rachita YadavDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Ayumi NishiyamaDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Deborah RaymondDepartment of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Viktoriya KatsnelsonDepartment of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Nikita UrvalDepartment of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Matthew SwanDepartment of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Vicki ShankerDepartment of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Joan MiraviteDepartment of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Ruth H WalkerDepartment of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Susan B BressmanDepartment of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Laurie J OzeliusDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
José C Cabassa *Department of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Rachel Saunders-Pullman *Department of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY, USA. Rachel.Saunders-Pullman@mountsinai.org.

Funding

Dissecting Oligogenic Biomarkers in Ashkenazi Jews with Parkinson DiseaseU01NS107016 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI OZELIUS, LAURIE J., SAUNDERS-PULLMAN, RACHEL · 2019 to 2023
$6.6M
Evaluation of glucocerebrosidase pathway biomarkers in Parkinson DiseaseU01NS094148 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAINC, DIMITRI, SAUNDERS-PULLMAN, RACHEL · 2015 to 2017
$1.4M
NINDS NIH HHS U01 NS094148NINDS NIH HHS U01 NS107016
6 · The paper itself

Abstract

There is a paucity of genetic characterization in people with Parkinson's disease (PD) of Latino and Afro-Caribbean descent. Screening LRRK2 and GBA variants in 32 New Yorkers of Puerto Rican ethnicity with PD and in 119 non-Hispanic-non-Jewish European PD cases revealed that Puerto Rican participants were more likely to harbor the LRRK2-p.G2019S variant (15.6% vs. 4.2%, respectively). Additionally, whole exome sequencing of twelve Puerto Rican and Dominican PD participants was performed as an exploratory study.

Identifiers

PMID38062033
PMCPMC10703927

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.