ReviewNature reviews. Disease primers2023
Degenerative mitral regurgitation.
Review in Nature reviews. Disease primers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Comparison of high-flow nasal cannula oxygen therapy versus nasal cannula in sedated transoesophageal echocardiography in patients with mitral regurgitation: a prospective, randomized controlled clinical trial.Journal of cardiothoracic surgery · 2026Trial
- Article
- Novel Direct Transcatheter Mitral Annuloplasty System: Preclinical Feasibility Study.JACC. Asia · 2026Article
- Mitral Valve Repair vs. Replacement: Hemodynamics in Valve Surgery.Reviews in cardiovascular medicine · 2026Review
- Minimally Invasive, Echocardiography-Guided Mouse Model of Degenerative Mitral Regurgitation Recapitulates Cardiac Remodeling and Arrhythmogenesis.Journal of the American Heart Association · 2026Article
- MitraNav: Design and Modeling of a Robotic System for Transseptal Mitral Valve Replacement with Dock Catheter Task-Space Control.Annals of biomedical engineering · 2026Article
- A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Unmasking Risk in Mitral Regurgitation: Prognostic Value of Exercise Stress Echocardiography-A Systematic Review.Journal of clinical medicine · 2026Review
- Social Disconnection, Genetic Risk, and the Incidence of Degenerative Valvular Heart Disease: A Population-Based Cohort Study.Journal of the American Heart Association · 2026Article
- Midterm Outcomes of Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation According to Anatomical Characteristics.Structural heart : the journal of the Heart Team · 2026Article
- Knowledge mapping and research trends in degenerative mitral regurgitation: a bibliometric analysis from 2004 to 2024.Journal of thoracic disease · 2026Article
- The global, regional, and national burden of non-rheumatic degenerative mitral valve disease from 1990 to 2021 and forecast for 2050.Frontiers in cardiovascular medicine · 2026Article
- Safety and Efficacy of Novel Morphology Classification-Guided Mitral Valve Transcatheter Edge-to-Edge Repair for Patients With Commissural Degenerative Mitral Regurgitation: Design and Rationale of the TEER-CD Trial.Reviews in cardiovascular medicine · 2025Article
- Article
- Association Between Rheumatoid Arthritis and the Risk of Incident Degenerative Valvular Heart Disease: Evidence From a Prospective Cohort Study.Journal of the American Heart Association · 2025Article
- Is mitral annular disjunction the cause of arrhythmogenic mitral valve prolapse?European heart journal · 2025Article
- Impact of Tricuspid Valve Repair on Less Than Moderate Tricuspid Regurgitation After Degenerative Mitral Repair.JACC. Asia · 2025Article
- Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis.European heart journal · 2025Article
- SimultaneousClinics (Sao Paulo, Brazil) · 2025Article
- Arrhythmic Mitral Valve Prolapse: Pathophysiology, Diagnostics, and Management Strategies.Seminars in thoracic and cardiovascular surgery · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 5 countries.
Funding
Abstract
Degenerative mitral regurgitation is a major threat to public health and affects at least 24 million people worldwide, with an estimated 0.88 million disability-adjusted life years and 34,000 deaths in 2019. Improving access to diagnostic testing and to timely curative therapies such as surgical mitral valve repair will improve the outcomes of many individuals. Imaging such as echocardiography and cardiac magnetic resonance allow accurate diagnosis and have provided new insights for a better definition of the most appropriate timing for intervention. Advances in surgical techniques allow minimally invasive treatment with durable results that last for ≥20 years. Transcatheter therapies can provide good results in select patients who are considered high risk for surgery and have a suitable anatomy; the durability of such repairs is up to 5 years. Translational science has provided new knowledge on the pathophysiology of degenerative mitral regurgitation and may pave the road to the development of medical therapies that could be used to halt the progression of the disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.