Evidence map›Paper›PMID 38061018›Full record

ReviewAnnual review of physiology2024

The Coding Logic of Interoception.

Ruiqi L Wang, Rui B Chang

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. The physiology of interoception and its adaptive role in consciousness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  10. Article
  11. Emergence of Functional Heart-Brain Circuits in a Vertebrate.bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ruiqi L WangDepartment of Neuroscience and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA; email: rui.chang@yale.edu.
Rui B ChangDepartment of Neuroscience and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA; email: rui.chang@yale.edu.
Yale University · US

Funding

Understanding the molecular and functional architecture of diverse body-brain pathwaysR01AT012041 · NCCIH · YALE UNIVERSITY · PI CHANG, RUI · 2022 to 2025
$3.0M
Understand the little brain on the heart: a molecular and functional dissection of the intrinsic cardiac nervous systemDP2HL151354 · NHLBI · YALE UNIVERSITY · PI CHANG, RUI · 2019 to 2019
$2.5M
A molecular and functional dissection of the vagal heart-to-brain physiological circuitsR01HL150449 · NHLBI · YALE UNIVERSITY · PI CHANG, RUI · 2020 to 2023
$1.7M
NCCIH NIH HHS R01 AT012041NHLBI NIH HHS DP2 HL151354NHLBI NIH HHS R01 HL150449
6 · The paper itself

Abstract

Interoception, the ability to precisely and timely sense internal body signals, is critical for life. The interoceptive system monitors a large variety of mechanical, chemical, hormonal, and pathological cues using specialized organ cells, organ innervating neurons, and brain sensory neurons. It is important for maintaining body homeostasis, providing motivational drives, and regulating autonomic, cognitive, and behavioral functions. However, compared to external sensory systems, our knowledge about how diverse body signals are coded at a system level is quite limited. In this review, we focus on the unique features of interoceptive signals and the organization of the interoceptive system, with the goal of better understanding the coding logic of interoception.

Indexed as

InteroceptionBrainCuesHumansLogicbody–brain axisinteroceptioninteroceptive codingsensoryvagus nerve

Identifiers

PMID38061018
PMCPMC11103614
OpenAlexW4389427746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.