Evidence map›Paper›PMID 38060844›Full record

ArticleMolecular pharmaceutics2024

Reverse Iontophoresis: Noninvasive Assessment of Topical Drug Bioavailability.

Kieran Moore, Sébastien Grégoire, Joan Eilstein, M Begoña Delgado-Charro, Richard H Guy

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Kieran MooreDepartment of Life Sciences, University of Bath, Claverton Down, Bath BA2 7AY, U.K.ORCID 0000-0003-1906-973X
Sébastien GrégoireL'Oréal Research and Innovation, 1 Av. Eugène Schueller, 93600 Aulnay-sous-Bois, France.
Joan EilsteinL'Oréal Research and Innovation, 1 Av. Eugène Schueller, 93600 Aulnay-sous-Bois, France.
M Begoña Delgado-CharroDepartment of Life Sciences, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
Richard H GuyDepartment of Life Sciences, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
University of Bath · GBL'Oréal (France) · FR

Funding

Assessing the skin pharmacokinetics of topical drugs, and the bio(in)equivalence of topical drug products, using non-invasive techniquesU01FD006533 · FDA · UNIVERSITY OF BATH · PI GUY, RICHARD H · 2018 to 2022
$1.2M
FDA HHS U01 FD006533
6 · The paper itself

Abstract

Assessing drug disposition in the skin after the application of a topical formulation is difficult. It is hypothesized that reverse iontophoresis (RI), which can extract charged/polar molecules for monitoring purposes, may provide a noninvasive approach for the assessment of local drug bioavailability. The passive and RI extraction of salicylic acid (SA) and nicotine (NIC) from porcine skin

Indexed as

IontophoresisSkinAnimalsBiological AvailabilityEpidermisHumansSkin AbsorptionSwinedermatopharmacokineticsnoninvasive drug monitoringreverse iontophoresisskintopical bioavailability

Identifiers

PMID38060844
PMCPMC10762657
OpenAlexW4389428044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.