Evidence map›Paper›PMID 38060815›Full record

ArticleCellular reprogramming2023

Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma.

Margarete M Karg, Yuancheng Ryan Lu, Nasrin Refaian, James Cameron, Emma Hoffmann, Cindy Hoppe, Shintaro Shirahama, Madhura Shah, Drenushe Krasniqi, Anitha Krishnan and 9 more

Open access · greenAbstract read
In one paragraph

Article in Cellular reprogramming, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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  14. The Role of Complement Dysregulation in Glaucoma.International journal of molecular sciences · 2024
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Margarete M KargSchepens Eye Research Institute of Mass Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Yuancheng Ryan LuPaul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-5982-3963
Nasrin RefaianSchepens Eye Research Institute of Mass Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
James CameronWhitehead Institute for Biomedical Research, Department of Biology, MIT, Cambridge, Massachusetts, USA.
Emma HoffmannSchepens Eye Research Institute of Mass Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Cindy HoppeSchepens Eye Research Institute of Mass Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Shintaro ShirahamaSchepens Eye Research Institute of Mass Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Madhura ShahSchepens Eye Research Institute of Mass Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Drenushe KrasniqiSchepens Eye Research Institute of Mass Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Anitha KrishnanSchepens Eye Research Institute of Mass Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Maleeka ShresthaSchepens Eye Research Institute of Mass Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Yinjie GuoSchepens Eye Research Institute of Mass Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Jennifer M CermakLife Biosciences LLC, Boston, Massachusetts, USA.
Michel WalthierLife Biosciences LLC, Boston, Massachusetts, USA.
Kasia BroniowskaLife Biosciences LLC, Boston, Massachusetts, USA.
Sharon Rosenzweig-LipsonLife Biosciences LLC, Boston, Massachusetts, USA.
Meredith Gregory-KsanderSchepens Eye Research Institute of Mass Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
David A SinclairPaul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Bruce R KsanderSchepens Eye Research Institute of Mass Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Massachusetts Eye and Ear Infirmary · USIgan Biosciences (United States) · USHebrew SeniorLife · USWhitehead Institute for Biomedical Research · US

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5M
Fas Ligand Cleavage regulates ocular homeostasis and glaucomaR01EY032762 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI GREGORY-KSANDER, MEREDITH, MARSHAK-ROTHSTEIN, ANN · 2022 to 2025
$2.5M
NEI NIH HHS P30 EY003790NEI NIH HHS R01 EY032762
6 · The paper itself

Abstract

Glaucoma, a chronic neurodegenerative disease, is a leading cause of age-related blindness worldwide and characterized by the progressive loss of retinal ganglion cells (RGCs) and their axons. Previously, we developed a novel epigenetic rejuvenation therapy, based on the expression of the three transcription factors

Indexed as

GlaucomaNeurodegenerative DiseasesAnimalsDisease Models, AnimalGenetic TherapyIntraocular PressureMiceRetinaaginggene therapyglaucomaneuronrejuvenationretina

Identifiers

PMID38060815
PMCPMC10739681
OpenAlexW4389429549

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.